Electroretinogram abnormalities in non-infectious uveitis often persist
Electroretinogram abnormalities in non-infectious uveitis often persist
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DOI：
10.1111/aos.14401
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发表时间：
2020-03-19
影响因子：
3.4
通讯作者：
de Boer, Joke H.
中科院分区：
文献类型：
--
作者：
Brouwer, Anna H.;de Wit, Gerard C.;de Boer, Joke H.
目的葡萄膜炎时，视锥细胞b波潜伏期延长是视网膜电图（ERG）的特征性异常。我们调查了这种情况是否会随着时间的推移而改善或恶化，以及哪些临床因素与变化有关。纳入非感染性葡萄膜炎患者。在葡萄膜炎发病的第一年测量ERG，一年后进行随访ERG。在隐式时间的锥b波的变化进行了研究，与临床参数，包括以下内容：人口统计学，葡萄膜炎的特点，治疗，最佳矫正视力，光学相干断层扫描参数和荧光素血管造影scores.Results的98只眼睛（63例），40显示了延长锥b波的第一ERG，其中10只眼睛改善。具有改善的ERG的眼睛更经常发生全葡萄膜炎，在第一次ERG期间，最初前房中的细胞发生率较高，在其随访ERG时消退。第一次ERG正常的58只眼中有5只眼睛的随访ERG恶化。这些眼睛在随访ERG时更频繁地出现活动性葡萄膜炎。在78只具有稳定视锥b波的眼中，16只在随访期间具有静止炎症。结论在大多数非感染性葡萄膜炎患者中，ERG异常似乎是不可逆的，即使当炎症变得静止。然而，一些ERG改善，这与全葡萄膜炎引起的前房炎症减少有关。相反，ERG恶化与炎症持续存在相关。
Purpose In uveitis, a prolonged implicit time of the cone b-wave is a characteristic electroretinogram (ERG) abnormality. We investigated whether this can improve or deteriorate over time and which clinical factors are associated with change.Methods Prospective cohort study. Patients with a non-infectious uveitis were included. An ERG was measured in the first year of uveitis onset and a follow-up ERG one year later. Changes in the implicit time of the cone b-wave were investigated in relation to clinical parameters including the following: demographics, uveitis characteristics, treatment, best-corrected visual acuity, optical coherence tomography parameters and fluorescein angiography scores.Results Of 98 eyes (63 patients), 40 showed a prolonged cone b-wave on the first ERG, which improved in 10 eyes. Eyes with an improved ERG more often had a panuveitis with initially a higher incidence of cells in the anterior chamber during the first ERG, which resolved at the time of their follow-up ERG. Five of the 58 eyes with a normal first ERG had a deteriorated follow-up ERG. These eyes had more frequently an active uveitis at the time of the follow-up ERG. Of the 78 eyes with a stable cone b-wave, 16 had a quiescent inflammation during follow-up. There were no differences in age or treatment.Conclusion In most patients with non-infectious uveitis, ERG abnormalities appear to be irreversible, even when the inflammation becomes quiescent. However, some ERGs improved, which was associated with reduction in inflammation of the anterior chamber due to panuveitis. In contrast, a worsened ERG was associated with a persistence of inflammation.