Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
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DOI：
10.1155/2008/426764
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Ota M
中科院分区：
文献类型：
--
作者：
Kitahara K;Kawa S;Katsuyama Y;Umemura T;Ozaki Y;Takayama M;Arakura N;Ota M
酒精滥用是慢性胰腺炎最常见的危险因素之一，但其潜在的病理生理机制尚不清楚。本研究的目的是通过筛选全基因组来确定导致酒精性慢性胰腺炎易感性或抵抗性的基因。本研究招募了65名酒精性慢性胰腺炎患者（63名男性和2名女性，平均年龄55.2岁）和99名健康日本对照者。这是一个关联研究，使用400个多态性微卫星标记，平均间距为10.8 cM分布在整个基因组。该搜索揭示了整个基因组中的10个候选易感区域和5个候选抗性区域。未检测到与先前报道的慢性胰腺炎易感基因相关的特异性微卫星标记，如PRSS 1、PRSS 2、CTRC、SPINK 1、CFTR、ALDH 2和CYP 2E1。在具有统计学显著性的标记中，染色体15q14上的D15S1007显示了疾病易感性的强有力证据（70.8%对35.1%，Pc = 0.0001）。在D15S1007的500kb内，有几个基因是ACP的候选易感基因，包括FMN1、DKFZP686C2281、LOC440268、RYR3和AVEN。
Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patients with alcoholic chronic pancreatitis (63 men and 2 women, mean age 55.2 years) and 99 healthy Japanese controls were enrolled in this study. This was an association study using 400 polymorphic microsatellite markers with an average spacing of 10.8 cM distributed throughout the whole genome. This search revealed 10 candidate susceptibility regions and 5 candidate resistant regions throughout the genome. No specific microsatellite markers were detected in association with previously reported susceptibility genes for chronic pancreatitis, such as PRSS1, PRSS2, CTRC, SPINK1, CFTR, ALDH2, and CYP2E1. Among the statistically significant markers, D15S1007 on chromosome 15q14 showed strong evidence for disease susceptibility (70.8% vs. 35.1%, Pc = 0.0001). Within 500 kb of D15S1007, several genes were candidate genes for susceptibility, including FMN1, DKFZP686C2281, LOC440268, RYR3, and AVEN, This study identified 10 candidate susceptibility and 5 candidate resistant regions that may contain genes involved in ACP pathogenesis.
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影响因子：
11.4
作者：
Bertocchini, F;Ovitt, CE;Sorrentino, V
通讯作者：
Sorrentino, V
DOI：
10.1073/pnas.0503215102
发表时间：
2005-10-04
影响因子：
11.1
作者：
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通讯作者：
Gorelick, FS
影响因子：
24.5
作者：
SARNER, M;COTTON, PB
通讯作者：
COTTON, PB
影响因子：
2.8
作者：
Chao, YC;Wang, SJ;Hsieh, TY
通讯作者：
Hsieh, TY
影响因子：
158.5
作者：
Sharer, N;Schwarz, M;Braganza, J
通讯作者：
Braganza, J