Potential dual imaging nanoparticle: Gd2O3 nanoparticle.
Potential dual imaging nanoparticle: Gd2O3 nanoparticle.
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DOI：
10.1038/srep08549
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发表时间：
2015-02-24
影响因子：
4.6
通讯作者：
Lee GH
中科院分区：
文献类型：
--
作者：
Ahmad MW;Xu W;Kim SJ;Baeck JS;Chang Y;Bae JE;Chae KS;Park JA;Kim TJ;Lee GH
Gadolinium (Gd) is a unique and powerful element in chemistry and biomedicine which can be applied simultaneously to magnetic resonance imaging (MRI), X-ray computed tomography (CT), and neutron capture therapy for cancers. This multifunctionality can be maximized using gadolinium oxide (Gd2O3) nanoparticles (GNPs) because of the large amount of Gd per GNP, making both diagnosis and therapy (i.e., theragnosis) for cancers possible using only GNPs. In this study, the T1 MRI and CT dual imaging capability of GNPs is explored by synthesizing various iodine compound (IC) coated GNPs (IC-GNPs). All the IC-GNP samples showed stronger X-ray absorption and larger longitudinal water proton relaxivities (r1 = 26–38 s−1mM−1 and r2/r1 = 1.4–1.9) than the respective commercial contrast agents. In vivo T1 MR and CT images of mice were also acquired, supporting that the GNP is a potential dual imaging agent.
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影响因子：
19.7
作者：
BLOEM, JL;WONDERGEM, J
通讯作者：
WONDERGEM, J
影响因子：
2.6
作者：
GIBSON, RJ;MEANOCK, CI;WALKER, TM
通讯作者：
WALKER, TM
影响因子：
3.4
作者：
Berry, Catherine C.
通讯作者：
Berry, Catherine C.
影响因子：
3.9
作者：
Corbierre, MK;Cameron, NS;Lennox, RB
通讯作者：
Lennox, RB
影响因子：
1.9
作者：
De Stasio, G;Rajesh, D;Pallini, R
通讯作者：
Pallini, R