Short-term environmental enrichment decreases the mnemonic response to estrogen in young, but not aged, female mice
Short-term environmental enrichment decreases the mnemonic response to estrogen in young, but not aged, female mice
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DOI：
10.1016/j.brainres.2007.05.033
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发表时间：
2007-07-30
期刊：
影响因子：
2.9
通讯作者：
Frick, Karyn M.
中科院分区：
文献类型：
--
作者：
Gresack, Jodi E.;Kerr, Kristin M.;Frick, Karyn M.
本研究旨在检查暴露于丰富的住房环境4周是否影响雌激素促进年轻和老年雌性小鼠物体识别的能力。使用一种新的对象识别任务测试对象识别。在物体识别测试之前和之后的整个过程中，将切除卵巢的年轻和年老雌性小鼠保持在标准或富集的圈养中4周。训练后立即向小鼠腹膜内注射溶剂或0.2 mg/kg 17 β-雌二醇，然后在24和48 h后重新测试。在年轻的女性，雌二醇单独改善对象识别在两个延迟相对于机会，效果不存在于丰富的女性雌二醇治疗。单独的丰富没有显着的影响，对象识别在年轻女性在任何延迟。相比之下，丰富的老年女性显着提高24小时和48小时的物体识别相对于机会，效果不存在于小鼠治疗的丰富和雌二醇。单独使用Eglutamine对老年女性的物体识别没有影响。总之，这些数据表明，雌二醇和丰富的单独差异影响对象识别在年轻和老年女性。然而，事实上，雌二醇和富集治疗的组合并没有影响物体识别在任何年龄表明，共同管理的两种治疗是最有效的单一治疗在每个年龄的效果较差。0 2007 Elsevier B. V.保留所有权利。
The present study was designed to examine if 4 weeks of exposure to an enriched housing environment affects the ability of estrogen to facilitate object recognition in young and aged female mice. Object recognition was tested using a novel object recognition task. Ovariectomized young and aged female mice were maintained in standard or enriched housing for 4 weeks prior to and then throughout object recognition testing. Immediately after training, mice were injected intraperitoneally with vehicle or 0.2 mg/kg 17 beta-estradiol and then were re-tested 24 and 48 h later. Among young females, estradiol alone improved object recognition at both delays relative to chance, an effect not present in enriched females treated with estradiol. Enrichment alone had no significant effect on object recognition in young females at either delay. In contrast, enrichment alone in aged females significantly enhanced both 24- and 48-h object recognition relative to chance, an effect not present in mice treated with both enrichment and estradiol. Estradiol alone had no effect on object recognition in aged females at either delay. Together, these data indicate that estradiol and enrichment alone differentially affect object recognition in young and aged females. However, the fact that the combination of estradiol and enrichment treatments did not affect object recognition at either age suggests that co-administration of both treatments is less effective than the most effective single treatment at each age. 0 2007 Elsevier B.V. All rights reserved.