CD133: a stem cell biomarker and beyond.
CD133: a stem cell biomarker and beyond.
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DOI：
10.1186/2162-3619-2-17
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发表时间：
2013-07-01
影响因子：
10.9
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Li Z
肿瘤干细胞（CSC）或肿瘤起始细胞（TIC）有助于肿瘤发生、转移、复发和化学抗性。CD133是一种五跨膜糖蛋白，自1999年发现以来，已被用作干细胞生物标志物，用于从各种正常和病理组织以及细胞系中分离干细胞样细胞。最近的研究集中在CD133的功能上。在这篇综述中，我们总结了新的见解CD133的调节和参与细胞自我更新，肿瘤发生，转移，耐药性，代谢，分化，自噬，凋亡和再生。
Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as well as cell lines since its discovery in 1999. Recent studies are focusing on the functionality of CD133. In this review, we summarize new insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration.