Cellular factors required for Lassa virus budding
Cellular factors required for Lassa virus budding
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DOI：
10.1128/jvi.80.8.4191-4195.2006
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发表时间：
2006-04-01
影响因子：
5.4
通讯作者：
Yasuda, J
中科院分区：
文献类型：
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作者：
Urata, S;Noda, T;Yasuda, J
已知拉沙病毒Z蛋白足以释放病毒样颗粒（VLP），并且在其C末端具有两个L结构域，PTAP和PPPY。然而，关于拉沙病毒出芽的细胞因子知之甚少。我们研究了哪些细胞因子用于拉沙病毒Z出芽。我们证明，拉沙Z蛋白有效地产生VLP，并使用细胞因子，Vps4A，Vps4B，和Tsg101，在出芽，这表明拉沙病毒出芽功能上使用多泡体途径。我们的数据可能为开发有效的抗拉沙病毒策略提供线索。
It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.