Novel BODIPY-based Ru(II) and Ir(III) metalla-rectangles: cellular localization of compounds and their antiproliferative activities
Novel BODIPY-based Ru(II) and Ir(III) metalla-rectangles: cellular localization of compounds and their antiproliferative activities
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DOI：
10.1039/c6cc00046k
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Lee, Chang Yeon
中科院分区：
文献类型：
--
作者：
Gupta, Gajendra;Das, Abhishek;Lee, Chang Yeon
报道了含BODIPY连接基的Ru(II)和Ir(III)金属矩形化合物[1](4+)-[4](4+)的第一个例子；其中一些化合物表现出高度选择性的抗癌活性，并与DNA和蛋白质发生强烈的相互作用。BODIPY配体特有的绿色荧光和相关的聚集诱导发射(AIE)使人们能够使用共聚焦显微镜观察细胞内的化合物。
The first examples of Ru(II) and Ir(III) metalla-rectangles [1](4+)-[4](4+) containing a BODIPY-based linker are reported; some of these compounds exhibited highly selective anticancer activity and interact strongly with DNA as well as protein. The characteristic green fluorescence of a BODIPY ligand and associated aggregation-induced emission (AIE) permitted visualization of compounds inside the cells using confocal microscopy.