Prospective cohort study of persistent hypertension following pre-eclampsia at Medani Hospital, Sudan
Prospective cohort study of persistent hypertension following pre-eclampsia at Medani Hospital, Sudan
复制标题
DOI：
10.1016/j.ijgo.2015.11.014
复制
发表时间：
2016-07-01
影响因子：
3.8
通讯作者：
Adam, Ishag
中科院分区：
文献类型：
--
作者：
Fadalallah, Zubaida M.;Elhassan, Elhassan M.;Adam, Ishag
目的：评价子痫前期患者持续性高血压的发生率及相关因素。方法：一项前瞻性队列研究纳入了2014年3月1日至10月31日在苏丹Wad Medani妇产医院出现的先兆子痫患者。分娩时和分娩后6周记录产科、临床和生化指标。结果：188名患者入组研究，其中165名患者有6周随访数据。其中轻度子痫前期136例（82.4%），重度子痫前期29例（17.6%）。在6周的随访中，58例（35.2%）患者出现持续性高血压。与6周血压正常的患者相比，持续性高血压患者在基线时血小板计数（P = 0.001）和分娩时新生儿体重（P < 0.001）显著降低。重度先兆子痫在持续高血压患者中比分娩后6周血压正常的患者更常见（P < 0.001）。在logistic回归分析中，所有被调查的因素都与持续高血压无关；然而，重度子痫前期患者发生持续性高血压的可能性是轻度子痫前期患者的7.3倍（95%可信区间1.6-32.2;P = 0.008）。结论：无论患者的年龄和胎次如何，苏丹发生子痫前期的患者（尤其是重度子痫前期）在分娩后6周持续高血压是常见的。(C) 2016年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To evaluate the incidence of, and factors associated with, persistent hypertension in patients with pre-eclampsia. Methods: A prospective cohort study enrolled patients presenting with pre-eclampsia at Wad Medani Maternity Hospital, Sudan, between March 1 and October 31, 2014. Obstetric, clinical, and biochemical variables were recorded at presentation and at 6 weeks after delivery. Results: Of 188 patients enrolled in the study, 6-week follow-up data were available for 165. Among these patients, 136 (82.4%) and 29 (17.6) had mild and severe pre-eclampsia, respectively. At 6-week follow-up, 58 (35.2%) patients were experiencing persistent hypertension. Patients with persistent hypertension demonstrated significantly lower platelet counts at baseline (P = 0.001) and neonatal weight at delivery (P < 0.001) than patients who were normotensive at 6 weeks. Severe pre-eclampsia was more common among patients who experienced persistent hypertension than those who were normotensive 6 weeks after delivery (P < 0.001). In a logistic-regression analysis, none of the investigated factors was associated with persistent hypertension; however, patients experiencing severe pre-eclampsia were 7.3-times more likely to experience persistent hypertension than patients with mild pre-eclampsia (95% confidence interval 1.6-32.2; P = 0.008). Conclusion: Persistent hypertension 6 weeks after delivery was common among patients who experienced pre-eclampsia in Sudan (particularly severe pre-eclampsia) regardless of patients' age and parity. (C) 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.