CIITA: a master regulator of adaptive immunity shows its innate side in the bone.
CIITA: a master regulator of adaptive immunity shows its innate side in the bone.
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CIITA：适应性免疫的主要调节剂在骨骼中显示出其先天的一面。
DOI：
10.1002/jbmr.2161
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Nakamura,MaryC
中科院分区：
文献类型：
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作者：
Nakamura,MaryC
主要组织相容性 II 类 (MHCII) 反式激活因子 (CIITA) 长期以来一直被认为是 MHCII 基因的主调节因子，对于正常免疫功能至关重要（Reith 及其同事 (1) 以及 Krawczyk 和 Reith (2) 进行了综述）。 CIITA 是一种非 DNA 结合共激活剂，专门调节 MHCII 分子的表达，CIITA 缺乏会导致罕见的人类免疫缺陷疾病，称为裸淋巴细胞综合征。(3) CIITA 还调节编码 MHCII 限制性抗原呈递所需的辅助蛋白的基因的表达，因此 CIITA 对于控制对外来抗原的反应和维持耐受性至关重要。(1, 2)
The major histocompatibility class II (MHCII) transactivator (CIITA) has long been known as the master regulator of MHCII genes, which are critical for normal immune function (reviewed in Reith and colleagues (1) and Krawczyk and Reith (2)). CIITA is a non–DNA‐binding coactivator that specifically regulates expression of MHCII molecules, with CIITA deficiency leading to the rare human immunodeficiency disease termed bare lymphocyte syndrome.(3) CIITA also regulates expression of genes encoding accessory proteins required for MHCII‐restricted antigen presentation, thus CIITA is central to controlling the response to foreign antigens and the maintenance of tolerance.(1, 2) In this issue of the