Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle
Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle
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DOI：
10.1186/s13567-020-00800-1
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发表时间：
2020-06-17
影响因子：
4.4
通讯作者：
Schulz-Schaeffer, Walter
中科院分区：
文献类型：
--
作者：
Dammann, Insa;Wemheuer, Wiebke M.;Schulz-Schaeffer, Walter
在一项最初旨在寻找牛海绵状脑病（BSE）潜在危险因素的研究中，我们共检查了403头荷斯坦弗里斯兰牛的组织。其中包括20头BSE牛及其236头出生和喂养队列动物加上32头后代，103头年龄、品种和地区匹配的对照牛以及另外12头具有神经系统体征的牛。除了obex外，我们还用组织学技术检查了腹腔神经节、颈颅神经节、三叉神经节和迷走神经近端神经节。出乎意料的是，我们发现了大量的神经纤维瘤，一种良性的周围神经鞘瘤，由雪旺细胞，成纤维细胞和神经周细胞组成。神经纤维瘤仅存在于腹腔神经节，并在组织学检查中发现。BSE牛及其队列（病例动物）中的频率为9.91%，年龄、品种和地区匹配的对照动物中的频率为9.09%，BSE和神经纤维瘤的发生之间似乎没有相关性。良性周围神经鞘瘤在牛中比在其他家畜中更常见。通常，它们是肉类检查过程中胸神经节中偶然的肉眼发现。据我们所知，以前没有系统的组织学研究，包括牛腹腔神经节在所有。腹腔神经节神经纤维瘤的高发病率可能在荷斯坦弗里斯兰牛经常发生的皱胃移位中起作用，因为肿瘤可能导致胃肠动力障碍。目前不能排除这些肿瘤的遗传易感性。
In a study originally designed to find potential risk factors for bovine spongiform encephalopathy (BSE) we examined tissues from 403 Holstein Frisian cattle in total. These included 20 BSE cattle and their 236 birth- and feeding cohort animals plus 32 offspring, 103 age, breed and district-matched control cattle and further twelve cattle with neurological signs. In addition to the obex, we examined the celiac ganglion, cervical cranial ganglion, trigeminal ganglion and proximal ganglion of the vagus nerve using histological techniques. Unexpectedly, we found a high number of neurofibroma, a benign peripheral nerve sheath tumor consisting of Schwann cells, fibroblasts and perineural cells. The neurofibroma were present only in the celiac ganglion and found during histologic examination. With a frequency of 9.91% in BSE cattle and their cohorts (case animals) and 9.09% in the age, breed and district matched control animals there seems to be no correlation between the occurrence of BSE and neurofibroma. Benign peripheral nerve sheath tumors have been described more often in cattle than in other domestic animals. Usually, they are incidental macroscopic findings in the thoracic ganglia during meat inspection. To our knowledge, there are no previous systematic histologic studies including bovine celiac ganglia at all. The high incidence of celiac ganglia neurofibroma may play a role in the frequently occurring abomasal displacements in Holstein Frisian cattle as the tumors might cause a gastrointestinal motility disorder. At present a genetic predisposition for these neoplasms cannot be ruled out.