Similarities and differences between the 'cytokine storms' in acute dengue and COVID-19.
Similarities and differences between the 'cytokine storms' in acute dengue and COVID-19.
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急性登革热和COVID-19中“细胞因子风暴”之间的相似性和差异。
DOI：
10.1038/s41598-020-76836-2
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发表时间：
2020-11-16
影响因子：
4.6
通讯作者：
Malavige GN
中科院分区：
文献类型：
--
作者：
Dayarathna S;Jeewandara C;Gomes L;Somathilaka G;Jayathilaka D;Vimalachandran V;Wijewickrama A;Narangoda E;Idampitiya D;Ogg GS;Malavige GN
新冠肺炎中的严重肺炎和多器官功能障碍以及登革出血热是两种疾病，它们可能与对感染病毒的免疫反应改变有关。为了确定这两种感染中细胞因子和趋化因子反应的异同，我们比较了不同严重程度的新冠肺炎和急性登革热患者在不同疾病时间点的反应。在疾病早期，进展为新冠肺炎重症肺炎和弥漫性心衰的患者IL-6、IL-10和MIP3α水平显著高于轻度患者。在早期疾病中，干扰素γ水平最低的是那些因新冠肺炎而死的人。中重度新冠肺炎患者血清IL-10(p = 0.0001)、IL-6(p = 0.002)、巨噬细胞炎性蛋白-3α(p = 0.02)和CD40-L水平(p = 0.002)在发病5~9天至10~21天均显著升高，而轻度患者则无明显升高。相比之下，这些细胞因子/趋化因子水平在DHF或登革热(DF)患者发热期和危重期保持不变。尽管新冠肺炎SP患者的IL-10水平显著升高，但DHF患者的IL-10水平是新冠肺炎SP患者的25倍，而新冠肺炎SP患者的IL-6水平是新冠肺炎SP患者的11倍。IL-10和其他细胞因子在早期疾病(≤ 4天)发生DF(n = 71)或DHF(n = )的较大队列患者中进行了评估。在评估的细胞因子中，IL-10在继续发展为DHF的患者中显著高于DF患者(p <； 0.0001)。在早期疾病期间，新冠肺炎和登革热中对SARS-CoV2的低干扰素γ反应以及高水平的免疫抑制IL-10都是抗病毒反应改变的指标，可能有助于疾病的严重性。
Severe pneumonia and multiorgan dysfunction in COVID-19 and dengue haemorrhagic fever (DHF) are two diseases that can associate with an altered immune response to the infecting virus. To determine the similarities and differences in the cytokine and chemokine responses in these two infections, we compared responses in patients with varying severity of COVID-19 and acute dengue at different time points of illness. During early disease, patients who proceeded to develop COVID-19 severe pneumonia (SP) and DHF had significantly higher levels of IL-6, IL-10 and MIP3α than those who developed mild illness. The lowest levels of IFNγ in early illness were seen in those who succumbed to their illness due to COVID-19. Levels of serum IL-10 (p = 0.0001), IL-6 (p = 0.002), MIP-3α (p = 0.02) and CD40-L levels (p = 0.002) significantly increased from 5 to 9 day of illness to 10–21 day of illness in patients with moderate-to-severe COVID-19, but not in those with mild illness. In contrast, these cytokine/chemokine levels remained unchanged in those with DHF or dengue fever (DF) during febrile and critical phases. Although IL-10 levels were significantly higher in COVID-19 patients with SP, patients with DHF had 25-fold higher levels, whereas IL-6 levels were 11-fold higher in those with COVID-19 SP. IL-10 and other cytokines were evaluated in a larger cohort of patients during early illness (≤ 4 days) who proceeded to develop DF (n = 71) or DHF (n = 64). Of the cytokines evaluated, IL-10 was significantly higher (p < 0.0001) in those who went on to develop DHF compared to DF. Low IFNγ response to the SARS-CoV2 and high levels of immunosuppressive IL-10 in both COVID-19 and dengue during early illness are indicators of an altered antiviral response potentially contributing to disease severity.
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DOI：
10.4269/ajtmh.2010.09-0552
发表时间：
2010-05-01
影响因子：
3.3
作者：
Gregory, Christopher J.;Santiago, Luis Manuel;Tomashek, Kay M.
通讯作者：
Tomashek, Kay M.
影响因子：
17.1
作者：
Beatty, P. Robert;Puerta-Guardo, Henry;Harris, Eva
通讯作者：
Harris, Eva
影响因子：
3.8
作者：
Friberg, Heather;Beaumier, Coreen M.;Rothman, Alan L.
通讯作者：
Rothman, Alan L.
影响因子：
5
作者：
Lippi, Giuseppe;Plebani, Mario;Henry, Brandon Michael
通讯作者：
Henry, Brandon Michael
影响因子：
3.8
作者：
Malavige, Gathsaurie Neelika;Jeewandara, Chandima;Ogg, Graham Stuart
通讯作者：
Ogg, Graham Stuart