Second to fourth digit ratio, adult testosterone level and testosterone deficiency
Second to fourth digit ratio, adult testosterone level and testosterone deficiency
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DOI：
10.1111/j.1464-410x.2011.10249.x
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发表时间：
2012-01-01
影响因子：
4.5
通讯作者：
Alcaraz, Antonio
中科院分区：
文献类型：
--
作者：
Garcia-Cruz, Eduardo;Huguet, Jorge;Alcaraz, Antonio
第二和第四手指长度的比例（2D/4D）与子宫内暴露于睾酮有关。2D/4D和成人激素模式之间的关系是有争议的。我们的研究的目的是确定是否有成人血清睾酮水平和2D/4D ratio.PATIENTS和METHODS之间的关系我们前瞻性地招募了204名连续患者，2008年1月和2009年6月之间的经直肠前列腺活检。所有病例均由同一名医生进行临床检查、2D/4D测量和经直肠活检，使用睾酮231和346 ng/dL（8和12 nmol/L）作为截断点。用左手上的游标卡尺进行2D/4D测定。年龄、体重、身高、体重指数、中毒习惯、直肠指检、前列腺特异性抗原和2D和4D测量值被前瞻性地记录。平均年龄为67 ± 7岁，平均睾酮水平为413 ± 18 ng/dL（14.33 +/- 0.62 nmol/L）。睾酮< 231 ng/dL的患者百分比（8 nmol/L）和睾酮< 346 ng/dL单因素分析显示，低2D/4D比值与高睾酮水平有关（B = -741.98; β =-0.165，P = 0.045），并且生化性腺功能减退症的患病率也较低（睾酮346 ng/dL低于睾酮
OBJECTIVESThe ratio of the second and fourth finger lengths (2D/4D) is related to intrauterine exposure to testosterone. The relationship between 2D/4D and adult hormonal pattern is controversial.The aim of our study was to determine if there was a relationship between adult serum testosterone levels and the 2D/4D ratio.PATIENTS AND METHODSWe prospectively recruited 204 consecutive patients referred for transrectal prostate biopsy between January 2008 and June 2009. The same physician performed clinical examinations, 2D/4D measurements and the transrectal biopsy in all cases.Cut-off points of 231 and 346 ng/dL testosterone (8 and 12 nmol/L) were used. 2D/4D determination was done with a vernier calliper on the left hand.The hormonal profile (testosterone and sexual hormone binding globulin) of the patients was determined between 7.00 am and 11.00 am.Age, weight, height, body mass index, toxic habits, digital rectal examination, prostate-specific antigen and 2D and 4D measurements were recorded prospectively.RESULTSThe mean age was 67 +/- 7 years and the mean testosterone level was 413 +/- 18 ng/dL (14.33 +/- 0.62 nmol/L).The percentages of patients with testosterone < 231 ng/dL (8 nmol/L) and testosterone < 346 ng/dL (12 nmol/L) were 6.1 and 30.6 respectively.Univariate analysis showed that low 2D/4D ratios were related to higher levels of testosterone (B = -741.98; beta = -0.165, P = 0.045) and also with low prevalence of biochemical hypogonadism (testosterone 346 ng/dL was lower than in patients with testosterone