The diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) compared to C-reactive protein (CRP) and procalcitonin (PCT) in children with systemic inflammatory response syndrome (SIRS)
The diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) compared to C-reactive protein (CRP) and procalcitonin (PCT) in children with systemic inflammatory response syndrome (SIRS)
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DOI：
10.1016/j.jiac.2016.08.015
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发表时间：
2017-01-01
影响因子：
2.2
通讯作者：
Bakir, Mustafa
中科院分区：
文献类型：
--
作者：
Sirinoglu, Melis;Soysal, Ahmet;Bakir, Mustafa
工作背景：本研究的目的是确定suPAR的诊断和预后价值，并将其与全身炎症反应综合征（SIRS）患儿的CRP和PCT进行比较。这项研究是在一所拥有649张床位的高等院校医院进行的。患者包括27名患有SIRS的儿童和27名没有任何感染或免疫抑制状况的对照组。结果：SIRS组和对照组入院第1天血清suPAR浓度的中位数（minemax）分别为10.06（2.7-57.46）和2.22（1.08-5.13）ng/Ml; SIRS组血清suPAR中位水平显著高于对照组（p < 0.05）。SIRS组死亡者血清suPAR水平显著高于存活者（p < 0.05）。在SIRS组中，suPAR的受试者工作特征曲线下面积（AUC（ROC））显示最佳截止值、灵敏度、特异性、NPV和PPV分别为0.978、3.8 ng/mL、96%、96%、96%和96%.Conclusions：我们得出结论：suPAR确实对SIRS儿童有诊断价值。此外，持续的高血清suPAR水平可预测儿童SIRS的死亡率。(C)2016年日本化疗学会和日本传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Background: The aim of the present study was to determine the diagnostic and prognostic values of suPAR and to compare them to CRP and PCT in pediatric patients with systemic inflammatory response syndrome (SIRS).Material-methods: A prospective case-control study was performed. The study was performed in a tertiary university hospital which has a 649-bed capacity. Patients included 27 children with SIRS and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4-7th days of the hospital stay.Results: The median (minemax) serum levels of suPAR obtained on the first day of the admission were 10.06 (2.7-57.46) and 2.22 (1.08-5.13) ng/Ml for the SIRS group and control group, respectively. The median serum levels of suPAR in the SIRS group was significantly higher than that in the control group (p < 0.05). The serum suPAR levels was significantly higher in nonsurvivors than in survivors in SIRS group (p < 0.05). In the SIRS group, the area under the receiver operating characteristics curve (AUC(ROC)) for suPAR revealed an optimum cut-off value, sensitivity, specificity, NPV and PPV of 0.978, 3.8 ng/mL, 96%, 96%, 96%, and 96%, respectively.Conclusions: We conclude that suPAR does have diagnostic value in children with SIRS. Additionally, persistent high serum suPAR level predicts mortality in SIRS in children. (C) 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.