In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan
In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan
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DOI：
10.1055/s-0028-1112208
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发表时间：
2009-03-01
期刊：
影响因子：
2.7
通讯作者：
Du, Guan-Hua
中科院分区：
文献类型：
--
作者：
Liu, Ai-Lin;Shu, Shi-Hui;Du, Guan-Hua
从苏木中分离得到6个对神经氨酸酶(NA)有抑制作用的化合物，分别为：Brazilein、Brazin、Protosappanin A、3-deoxaspanchalcon、Sappanchalcon和Rhamnetin。用细胞病变效应(CPE)降低法评价其体外抗流感病毒活性。结果表明，与阳性对照奥司他韦酸和利巴韦林的IC50值分别为0.065和9.17mU g/mL相比，3-脱氧皂苷查尔酮和皂苷查尔酮对H3N2流感病毒的IC50值最高，分别为1.0 6mU g/m L和2.0 6mU g/m L。
Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 mu g/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 mu g/mL, respectively.