Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis.
Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis.
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DOI：
10.3164/jcbn.15-54
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发表时间：
2016-01
影响因子：
2.4
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Dai Y;Zhu J;Meng D;Yu C;Li Y
关于血浆同型半胱氨酸水平升高与非酒精性脂肪肝之间的关系，以往的研究报道了不一致的结果。我们旨在通过进行荟萃分析来研究这种关联。在PubMed上检索了从开始到2015年1月的文献。纳入了8项评估经活检证实的非酒精性脂肪肝受试者与健康对照者相比血浆同型半胱氨酸水平的研究。与对照组相比，非酒精性脂肪肝患者的同型半胱氨酸水平更高[标准平均差（SMD）：0.66 µmol/L，95% CI：0.41，0.92 µmol/L]，并且与高同型半胱氨酸血症的风险显著增加相关[比值比（OR）5.09，95% CI：1.69，15.32]。此外，非酒精性脂肪肝患者的同型半胱氨酸水平比健康对照组高0.45 µmol/L（95% CI：0.09，0.82 µmol/L），而非酒精性脂肪性肝炎患者的同型半胱氨酸水平高1.02 µmol/L（95% CI：0.28，1.76 µmol/L）。非酒精性脂肪性肝病患者与健康对照者之间叶酸水平和维生素B12水平无差异。这项研究表明，非酒精性脂肪肝患者血清同型半胱氨酸浓度升高，并与高同型半胱氨酸血症的风险增加有关。需要进一步的研究来证明高同型半胱氨酸血症在非酒精性脂肪性肝病中的因果作用。
Previous studies have reported inconsistent findings regarding the association between plasmatic higher of homocysteine level and non-alcoholic fatty liver disease. We aimed to investigate this association by conducting a meta-analysis. Literature was searched on PubMed from inception to January 2015. Eight studies evaluating plasma level of homocysteine in biopsy-proven non-alcoholic fatty liver disease subjects compared to healthy controls were included. Compared with the controls, non-alcoholic fatty liver disease patients witnessed a higher level of homocysteine [standard mean difference (SMD): 0.66 µmol/L, 95% CI: 0.41, 0.92 µmol/L], and were associated with a significant increased risk for hyperhomocysteinemia [odds ratio (OR) 5.09, 95% CI: 1.69, 15.32]. In addition, patients with non-alcoholic fatty liver presented 0.45 µmol/L higher levels of homocysteine compared to healthy controls (95% CI: 0.09, 0.82 µmol/L), whereas non-alcoholic steatohepatitis patients had 1.02 µmol/L higher levels of homocysteine (95% CI: 0.28, 1.76 µmol/L). There was neither difference of folate level nor vitamin B12 level between non-alcoholic fatty liver disease subjects and healthy controls. This study revealed that non-alcoholic fatty liver disease patients presented an increased serum concentration of homocysteine, and were associated with an increased risk of hyperhomocysteinemia. Further studies are needed to demonstrate a causal role of hyperhomocysteinemia in non-alcoholic fatty liver disease.