BK virus DNA: complete nucleotide sequence of a human tumor virus.
BK virus DNA: complete nucleotide sequence of a human tumor virus.
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BK病毒DNA：人类肿瘤病毒的完整核苷酸序列。
作者：
R. Yang;R. Wu
给出了人乳多空病毒 BK 的完整 DNA 序列。从BK病毒（MM株）的4963个碱基对序列中，可以推导出至少5种蛋白质的氨基酸序列：T抗原和t抗原，它们共用氨基端肽；蛋白质VP2和VP3，共有232个氨基酸； VP1 蛋白，其编码序列与 VP2 和 VP3 的编码序列重叠 113 个核苷酸，但在不同的框架中读取。 BK病毒和猿猴病毒40（SV40）的基因位点和基因排列惊人相似。 BK病毒中推导的蛋白质序列与SV40中的蛋白质序列具有73%的氨基酸同源性，而两种病毒的DNA序列具有70%的同源性，表明密切的进化关系。然而，这些病毒非编码区的重复DNA序列是不同的。
The complete DNA sequence of the human papovavirus BK is presented. From the 4963 base-pair sequence of BK virus (MM strain), the amino acid sequence of at least five proteins can be deduced: a T antigen and a t antigen, which share amino terminal peptides; proteins VP2 and VP3, which share 232 amino acids; and protein VP1, whose coding sequence overlaps those for VP2 and VP3 by 113 nucleotides but is read in a different frame. The gene loci and the arrangement of genes are strikingly similar in BK virus and simian virus 40 (SV40). The sequence of the deduced proteins in BK virus shares 73 percent amino acid homology with those in SV40, whereas the DNA sequence of the two viruses shares 70 percent homology, suggesting close evolutionary relationship. However, the repeated DNA sequences in the noncoding regions of these viruses are different.