Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes
Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes
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DOI：
10.1016/j.atherosclerosis.2013.01.016
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发表时间：
2013-04-01
期刊：
影响因子：
5.3
通讯作者：
Shimomura, Iichiro
中科院分区：
文献类型：
--
作者：
Fujisawa, Keiko;Katakami, Naoto;Shimomura, Iichiro
循环可溶性AGE受体（sRAGE）是否与糖尿病患者动脉粥样硬化相关仍存在争议。在这项研究中，我们招募了276名没有心血管疾病（CVD）史的日本2型糖尿病患者，评估了他们的基线临床和生化数据，包括血清sRAGE水平，并前瞻性地评估了这些参数与CVD事件之间的关系。中位随访期为5.6年，有25例新的CVD事件。结果显示，血清sRAGE水平越高，CVD事件发生的风险越高（趋势p = 0.046）。多因素Cox比例风险回归分析显示，血清sRAGE水平与CVD独立相关（HR / 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034），即使在调整了常规冠状动脉危险因素后也是如此。总之，在日本2型糖尿病患者中，sRAGE水平升高与CVD风险增加相关。2013爱思唯尔爱尔兰有限公司版权所有。
It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events.The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors.In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.