Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
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DOI：
10.1016/j.vaccine.2011.02.017
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发表时间：
2011-04-05
期刊：
影响因子：
5.5
通讯作者：
Pasetti, Marcela F.
中科院分区：
文献类型：
--
作者：
Chen, Wilbur H.;Cross, Alan S.;Pasetti, Marcela F.
在接受标准剂量的三价灭活流感疫苗（每种病毒株含15 μ g血凝素（HA））或高剂量疫苗（每种病毒株含60 μ g HA）的非卧床健康老年人和年轻人中，对抗体和细胞介导的免疫应答进行了比较分析。在老年人中，高剂量疫苗诱导的HAI（血凝抑制）和病毒中和抗体滴度高于标准剂量疫苗。然而，这些反应没有达到标准剂量疫苗在年轻成人中诱导的反应程度。在免疫后的老年人和年轻人中检测到产生IFN-γ的疫苗特异性循环T细胞。然而，各组间IFN-γ反应无显著差异。另一方面，在老年人中，标准剂量疫苗导致完全无应答者的比例最高，这些完全无应答者未能引起HAI或IFN-γ应答。这项研究提供了进一步的证据表明，老年人接种更高剂量的疫苗可能会导致免疫应答增强，预计这将提高保护作用，尽管其程度仍低于年轻健康个体的免疫应答。(C)2011爱思唯尔有限公司保留所有权利。
A comparative analysis of antibody and cell-mediated immune responses was performed in ambulatory medically stable elderly and young adults who received the standard-dose of trivalent inactivated influenza vaccine, containing 15 mu g of hemagglutinin (HA) per virus strain, or a high-dose vaccine containing 60 mu g HA per virus strain. Among the elderly, the high dose vaccine induced greater HAI (hemagglutination inhibition) and virus neutralization antibody titers than the standard dose vaccine. These responses, however, did not achieve the magnitude of those induced by the standard dose vaccine in young adults. Vaccine-specific circulating T cells producing IFN-gamma were detected in the elderly and young adults following immunization. However, there were no significant differences in the IFN-gamma responses among groups. On the other hand, the standard dose vaccine in the elderly resulted in the highest proportion of complete non-responders who failed to elicit either an HAI or an IFN-gamma response. This study provides further evidence that a higher dose vaccine for the elderly may result in enhanced immune responses which are predicted to improve protection although still of lower magnitude than those induced in younger healthier individuals. (C) 2011 Elsevier Ltd. All rights reserved.