Amnesia as an Adverse Event Associated With Fentanyl: An Analysis of the US Food and Drug Administration Adverse Event Reporting System, 2011-2021.
Amnesia as an Adverse Event Associated With Fentanyl: An Analysis of the US Food and Drug Administration Adverse Event Reporting System, 2011-2021.
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失忆症是与芬太尼相关的不良事件：美国食品和药物管理局不良事件报告系统分析，2011-2021 年。
DOI：
10.1097/ana.0000000000000901
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发表时间：
2024
影响因子：
3.7
通讯作者：
DeMariaJr,Alfred
中科院分区：
文献类型：
--
作者：
Barash,JedA;Kofke,WAndrew;DeMariaJr,Alfred
致编辑：在过去的十年中，美国各地的医生描述了一种急性遗忘综合征，其特征是在阿片类药物滥用（特别是涉及芬太尼）的情况下，脑成像中的双侧海马异常。这种罕见的阿片类药物相关遗忘综合征（OAS）患者表现出明显的顺行性和轻度逆行性记忆丧失，持续数周至数月或更长时间。有时，OAS最初在药物过量后气管拔管后观察到，但通常在没有已知伴随事件的情况下发生。1-3通过μ受体的刺激，芬太尼和其他阿片类药物被认为通过抑制抑制性中间神经元诱导海马过度兴奋，这是导致OAS的可能机制。4然而，临床环境中与芬太尼使用相关的OAS病例的缺乏被认为是阿片类药物在该综合征病理生理学中的确切作用的不确定性领域。5，6虽然记录临床使用导致的罕见疾病的频率是一个独特的挑战，但美国食品药品监督管理局（FDA）不良事件报告系统（FAERS）提供了一种替代方法来估计这种现象的发生率。旨在协助药物和生物
To the Editor: Over the past decade, physicians across the United States have described an acute amnestic syndrome distinguished by bilateral hippocampal abnormalities on brain imaging in the setting of opioid misuse, particularly involving fentanyl. Patients with this rare opioid-associated amnestic syndrome (OAS) demonstrate marked anterograde and milder retrograde memory loss for weeks to months or longer. At times, OAS is initially observed after tracheal extubation after an overdose, but often occurs without a known concomitant event. 1–3 Through the stimulation of mu receptors, fentanyl and other opioids are thought to induce hippocampal hyperexcitability by inhibition of inhibitory interneurons, a possible mechanism contributing to OAS. 4 However, the dearth of OAS cases associated with fentanyl use in clinical settings has been raised as an area of uncertainty as to the exact role of opioids in the pathophysiology of this syndrome. 5, 6Although documenting the frequency of a rare condition attributable to clinical use poses a unique challenge, the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) offers a surrogate method to estimate the occurrence of this phenomenon. Intended to assist in drug and biological
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对“应用现有症状监测系统量化马萨诸塞州阿片类药物相关遗忘综合症可能病例”的评论。
影响因子：
5.5
作者：
R. Dutton
通讯作者：
R. Dutton
更多关于与芬太尼过量相关的急性遗忘综合症的信息。
DOI：
10.1056/nejmc1805681
发表时间：
2018
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jed A Barash;M. Ganetsky;Alfred DeMaria
通讯作者：
Alfred DeMaria
影响因子：
4.4
作者：
Barash, Jed A.;Whitledge, James;Ganetsky, Michael
通讯作者：
Ganetsky, Michael
DOI：
10.15585/mmwr.mm6603a2
发表时间：
2017-01-27
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Barash JA;Somerville N;DeMaria A Jr
通讯作者：
DeMaria A Jr