Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia.
Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia.
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DOI：
10.1128/mbio.00884-14
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发表时间：
2014-02-25
期刊：
影响因子：
6.4
通讯作者：
Lipkin WI
中科院分区：
文献类型：
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作者：
Alagaili AN;Briese T;Mishra N;Kapoor V;Sameroff SC;Burbelo PD;de Wit E;Munster VJ;Hensley LE;Zalmout IS;Kapoor A;Epstein JH;Karesh WB;Daszak P;Mohammed OB;Lipkin WI
中东呼吸综合征（MERS）被认为是一种人畜共患疾病;然而，病原体MERS冠状病毒的储存库和传播机制尚不清楚。单峰骆驼也有牵连，因为有报告说，一些受害者曾接触过骆驼，出现这种疾病的地区的骆驼有病毒抗体，从骆驼身上发现的病毒序列与人类之间的疾病爆发有关。尽管如此，骆驼是否介导了向人类的传播还没有得到解决。在这里，我们提供了来自沙特阿拉伯王国骆驼的地理和时间调查的证据，表明MERS冠状病毒至少自1992年以来一直在骆驼中传播，在全国范围内分布，并且可以在遗传学上分类为与人类疾病爆发相关的分支。我们没有发现家养绵羊或家养山羊感染的证据。本研究旨在确定沙特阿拉伯王国单峰骆驼和其他牲畜中东呼吸综合征（MERS）冠状病毒感染的历史和当前流行率，其中报告了指示病例和大多数MERS病例。
The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic and temporal survey of camels in the Kingdom of Saudi Arabia that MERS coronaviruses have been circulating in camels since at least 1992, are distributed countrywide, and can be phylogenetically classified into clades that correlate with outbreaks of the disease among humans. We found no evidence of infection in domestic sheep or domestic goats. This study was undertaken to determine the historical and current prevalence of Middle East respiratory syndrome (MERS) coronavirus infection in dromedary camels and other livestock in the Kingdom of Saudi Arabia, where the index case and the majority of cases of MERS have been reported.