Magnetic Heating of Iron Oxide Nanoparticles and Magnetic Micelles for Cancer Therapy.
Magnetic Heating of Iron Oxide Nanoparticles and Magnetic Micelles for Cancer Therapy.
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DOI：
10.1109/tmag.2012.2222359
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发表时间：
2013-01
影响因子：
2.1
通讯作者：
Brazel CS
中科院分区：
文献类型：
--
作者：
Glover AL;Bennett JB;Pritchett JS;Nikles SM;Nikles DE;Nikles JA;Brazel CS
研究了将磁性纳米粒子纳入嵌段共聚物胶束中，以开发用于癌症治疗的靶向磁性触发药物递送系统。在此，我们报告了磁性纳米颗粒和聚（乙二醇-b-己内酯）嵌段共聚物的合成，并对纳米颗粒的磁加热、嵌段共聚物自组装形成磁性胶束以及热增强药物释放进行了实验验证。胶束的半结晶核心在略高于生理条件的温度下熔化，表明它们可用于从热响应聚合物系统中释放化疗药物。研究表明，磁性纳米粒子在 30-70 kA/m 的高频磁场中可以有效加热。磁性胶束还表现出加热特性，当与化疗剂和靶向配体结合时，可以开发用于局部触发药物输送。在磁加热实验期间，在磁性胶束的温度曲线中观察到时间滞后，这可能是由于在本体溶液温度升高之前聚己内酯胶束核熔化的熔化热。当胶束被加热到核心熔点以上时，掺入胶束中的阿霉素释放得更快。
The inclusion of magnetic nanoparticles into block copolymer micelles was studied towards the development of a targeted, magnetically triggered drug delivery system for cancer therapy. Herein, we report the synthesis of magnetic nanoparticles and poly(ethylene glycol-b-caprolactone) block copolymers, and experimental verification of magnetic heating of the nanoparticles, self-assembly of the block copolymers to form magnetic micelles, and thermally-enhanced drug release. The semicrystalline core of the micelles melted at temperatures just above physiological conditions, indicating that they could be used to release a chemotherapy agent from a thermo-responsive polymer system. The magnetic nanoparticles were shown to heat effectively in high frequency magnetic fields ranging from 30–70 kA/m. Magnetic micelles also showed heating properties, that when combined with a chemotherapeutic agent and a targeting ligand could be developed for localized, triggered drug delivery. During the magnetic heating experiments, a time lag was observed in the temperature profile for magnetic micelles, likely due to the heat of fusion of melting of polycaprolactone micelle cores before bulk solution temperatures increased. Doxorubicin, incorporated into the micelles, released faster when the micelles were heated above the core melting point.