A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China.
A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China.
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中国产前铊暴露与低出生体重的病例对照研究
DOI：
10.1289/ehp.1409202
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发表时间：
2016-01
影响因子：
10.4
通讯作者：
Xu S
中科院分区：
文献类型：
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作者：
Xia W;Du X;Zheng T;Zhang B;Li Y;Bassig BA;Zhou A;Wang Y;Xiong C;Li Z;Yao Y;Hu J;Zhou Y;Liu J;Xue W;Ma Y;Pan X;Peng Y;Xu S
铊（Tl）是一种广泛存在于环境中的剧毒重金属。病例报告表明，母亲在怀孕期间暴露于高水平的Tl与低出生体重（LBW）相关，但流行病学数据有限。本研究旨在评估产前Tl暴露是否与LBW风险增加相关。这项病例对照研究于2012年至2014年在中国湖北省进行，涉及816名研究参与者（204例LBW病例和612例匹配对照）。在分娩时收集的母体尿液中测量Tl浓度，并使用条件逻辑回归评估与LBW的关联。较高的母体尿Tl水平与LBW风险增加显著相关[粗比值比（OR）= 1.52; 95%CI：1.00，最高与最低三分位数为2.30]，并且在调整潜在混杂因素后，该相关性类似地升高（调整OR = 1.90; 95%CI：1.01，最高与最低三分位数为3.58）。分层分析显示，对于< 28岁的母亲和家庭收入较低的母亲，LBW的风险估计值略高，与较高的Tl水平相关;然而，根据母亲年龄（异质性p = 0.18）或家庭收入（异质性p = 0.28），没有统计学证据表明风险异质性。据我们所知，我们是第一个调查产前Tl暴露与LBW之间关系的病例对照研究。结果表明，产前暴露于高水平的Tl可能与LBW的风险增加有关。Xia W，Du X，Zheng T，Zhang B，Li Y，Bassig BA，Zhou A，Wang Y，Xiong C，Li Z，Yao Y，Hu J，Zhou Y，Liu J，Xue W，Ma Y，Pan X，Peng Y，Xu S. 2016.中国产前铊暴露与低出生体重的病例对照研究环境健康展望124：164-169; http://dx.doi.org/10.1289/ehp.1409202
Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. This study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW. This case–control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012–2014. Tl concentrations were measured in maternal urine collected at delivery, and associations with LBW were evaluated using conditional logistic regression. Higher maternal urinary Tl levels were significantly associated with increased risk of LBW [crude odds ratio (OR) = 1.52; 95% CI: 1.00, 2.30 for the highest vs. lowest tertile], and the association was similarly elevated after adjustment for potential confounders (adjusted OR = 1.90; 95% CI: 1.01, 3.58 for the highest vs. lowest tertile). Stratified analyses showed slightly higher risk estimates for LBW associated with higher Tl levels for mothers < 28 years old and for mothers with lower household income; however, there was no statistical evidence of heterogeneity in risk according to maternal age (p for heterogeneity = 0.18) or household income (p for heterogeneity = 0.28). To our knowledge, ours is the first case–control study to investigate the association between prenatal Tl exposure and LBW. The results suggest that prenatal exposure to high levels of Tl may be associated with an increased risk of LBW. Xia W, Du X, Zheng T, Zhang B, Li Y, Bassig BA, Zhou A, Wang Y, Xiong C, Li Z, Yao Y, Hu J, Zhou Y, Liu J, Xue W, Ma Y, Pan X, Peng Y, Xu S. 2016. A case–control study of prenatal thallium exposure and low birth weight in China. Environ Health Perspect 124:164–169; http://dx.doi.org/10.1289/ehp.1409202