Elastic laminal invasion in colon cancer: diagnostic utility and histological features.
Elastic laminal invasion in colon cancer: diagnostic utility and histological features.
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DOI：
10.3389/fonc.2012.00179
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发表时间：
2012
影响因子：
4.7
通讯作者：
Ochiai A
中科院分区：
文献类型：
--
作者：
Kojima M;Yokota M;Saito N;Nomura S;Ochiai A
结直肠癌的原发肿瘤是根据肿瘤是否扩散到肠壁进行病理评估的。对可能与pT4相关的浆膜受累程度的评估对病理学家来说是具有挑战性的，使得诊断的一致性值得怀疑。为了解决这个问题，可以采取以下两种策略。一种方法是使用特殊染色或免疫组织化学染色技术来辅助诊断。另一个目标是构建评估肿瘤扩散的建议，并就用于评估肿瘤扩散的标准达成世界范围的共识。我们之前报道过，使用弹性染色可以客观地确定腹膜弹性层压浸润（ELI），并且可能有助于简化和更客观地分层腹膜表面周围深部肿瘤浸润。我们还注意到取样、染色和组织解剖学知识在常规病理诊断中应用弹性染色的重要性。在此，我们回顾原发肿瘤分层的历史，从而得出目前的TNM分类，并报告我院所做的病理评估的现状，总结结直肠癌患者肿瘤扩散的病理诊断已经建立的内容和进一步需要做的工作。
Primary tumors of the colorectal cancers are assessed pathologically based on the tumor spread into the bowel wall. The assessment of serosal involvement, which may be relevant to pT4, can be challenging for pathologists, making the consistency of diagnoses questionable. As solutions to this problem, the following two strategies could be adopted. One would be to use special staining or immunohistochemical staining techniques for diagnostic assistance. The other would be to construct recommendations for the assessment of tumor spreading and to obtain a world-wide consensus on the criteria used to assess tumor spreading. Using elastic staining, we previously reported that peritoneal elastic laminal invasion (ELI) could be objectively determined and would likely contribute to a simplified and more objective stratification of deep tumor invasion around the peritoneal surface. We also noted the importance of sampling, staining, and histo-anatomical knowledge in the application of elastic staining during routine pathological diagnosis. Here we review the history of primary tumor stratification leading to the present TNM classification and report on the current status of pathological assessments made at our hospital to summarize what has been established and what is further required for the pathological diagnosis of tumor spreading in patients with colorectal cancer.