ANTIBODIES TO SM IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION OF SM ANTIBODY-TITERS WITH DISEASE-ACTIVITY AND OTHER LABORATORY PARAMETERS
ANTIBODIES TO SM IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION OF SM ANTIBODY-TITERS WITH DISEASE-ACTIVITY AND OTHER LABORATORY PARAMETERS
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DOI：
10.1002/art.1780241003
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
TAYLOR, RP
中科院分区：
文献类型：
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作者：
BARADA, FA;ANDREWS, BS;TAYLOR, RP
对 30 名系统性红斑狼疮 (SLE) 患者进行了为期 2.5 年的研究。该组被分为 14 名具有 [核抗原] Sm 抗体的患者和在研究期间未表现出 Sm 抗体的对照组。所有 14 例患者的 Sm 抗体滴度都有波动。Sm 抗体滴度的上升预示着 50% 的疾病发作，并且与 60% 的疾病恶化相关。具有 Sm 抗体的患者严重疾病、肾脏疾病和中枢神经系统疾病的发生率相当。他们表现出明显更多的白细胞减少症和针对非 Sm、非 RNP [核糖核蛋白]可提取核抗原的抗体。仅在 1 名患者中，Sm 抗体滴度的升高与 SLE 的其他血清学标志物（特别是双链 DNA 和冷球蛋白抗体）相反，与疾病发作无关或预测疾病发作。尽管很少检测到，但 Sm 抗体可以帮助治疗 SLE 患者。
Thirty patients with systemic lupus erythematosus (SLE) were studied over a 2.5 yr period. The group was divided into 14 patients with antibodies to [the nuclear antigen] Sm and a control group which failed to exhibit antibodies to Sm over the study period. The titer of antibodies to Sm fluctuated in all 14. A rising titer of antibodies of Sm predicted a flare of disease in 50% and correlated with an exacerbation of disease in 60%. Patients with antibodies to Sm had a comparable incidence of severe disease, renal disease and CNS disease. They exhibited significantly more leukopenia and antibodies to non-Sm, non-RNP [ribonucleoprotein] extractable nuclear antigen. In only 1 patient, a rise in titer of antibodies to Sm did not correlate with or predict a disease flare in contradistinction to other serologic markers of SLE, specifically antibodies to double-stranded DNA and cryoglobulins. Though infrequently detected, antibodies to Sm can help in the management of patients with SLE.