Levels of saliva cotinine in electronic cigarette users
Levels of saliva cotinine in electronic cigarette users
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DOI：
10.1111/add.12475
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发表时间：
2014-05-01
期刊：
影响因子：
6
通讯作者：
Etter, Jean-Francois
中科院分区：
文献类型：
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作者：
Etter, Jean-Francois
目的评估唾液可替宁水平在有经验的用户的电子烟（'vapers'）。设计，设置和participantsAn互联网调查在2011年和2012年，收集唾液小瓶通过邮件。参与者是71名电子烟用户，主要在网站和电子烟在线论坛上注册。测量电子烟、烟草和尼古丁药物的使用。通过邮件收集唾液并通过液相色谱-质谱法分析可替宁。发现大多数参与者（89%）是前吸烟者，大多数（92%）每天使用电子烟，平均使用电子烟12个月，每天平均吸150次电子烟[平均= 220次/天，95%置信区间（CI）= 169-271]。补充液中尼古丁的中位浓度为16 mg/ml（平均值= 16.4，95% CI = 14.5-18.3）。在过去5天内没有使用任何烟草或尼古丁药物的62名电子烟使用者中，可替宁水平中位数为353 ng/ml（平均值= 374，95% CI = 318-429），可替宁与电子烟液中尼古丁浓度之间的相关性为r = 0.33（P = 0.013），可替宁与戒烟前每日吸烟量的相关性为r = 0.48（P < 0.001）.结论至少一些有经验的电子烟使用者似乎能够从这些产品中获得与吸烟者一样多的尼古丁。
AimsTo assess saliva cotinine levels in experienced users of e-cigarettes ('vapers').Design, setting and participantsAn internet survey in 2011 and 2012, with collection of saliva vials by mail. Participants were 71 users of e-cigarettes enrolled mainly on websites and online forums dedicated to e-cigarettes.MeasurementsUse of e-cigarettes, tobacco and nicotine medications. Collection of saliva by mail and analysis of cotinine by liquid chromatography-mass spectrometry.FindingsMost participants (89%) were former smokers, most (92%) were using e-cigarettes daily, had been using e-cigarettes for 12 months on average and puffed a median of 150 times per day on their e-cigarettes [mean = 220 puffs/day, 95% confidence interval (CI) = 169-271]. The median concentration of nicotine in refill liquids was 16 mg/ml (mean = 16.4, 95% CI = 14.5-18.3). In the 62 e-cigarette users who, in the past 5 days, had not used any tobacco or nicotine medications, the median cotinine level was 353 ng/ml (mean = 374, 95% CI = 318-429), the correlation between cotinine and nicotine concentration in e-liquids was r = 0.33 (P = 0.013), and the correlation between cotinine and the number of cigarettes smoked per day before quitting smoking was r = 0.48 (P < 0.001).ConclusionsAt least some experienced users of electronic cigarettes appear to be able to gain as much nicotine from those products as do cigarette smokers.