Structures of Phytophthora RXLR Effector Proteins A CONSERVED BUT ADAPTABLE FOLD UNDERPINS FUNCTIONAL DIVERSITY
Structures of Phytophthora RXLR Effector Proteins A CONSERVED BUT ADAPTABLE FOLD UNDERPINS FUNCTIONAL DIVERSITY
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DOI：
10.1074/jbc.m111.262303
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发表时间：
2011-10-14
影响因子：
4.8
通讯作者：
Banfield, Mark J.
中科院分区：
文献类型：
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作者：
Boutemy, Laurence S.;King, Stuart R. F.;Banfield, Mark J.
植物病原体在宿主植物细胞内递送效应蛋白以促进感染。这些蛋白质也可以被植物免疫系统感知，从而限制病原体的生长。效应基因可以显示积极选择和快速进化的特征，这可能是它们与植物共同进化军备竞赛的结果。效应子如何进化以获得新的毒力功能和/或逃避植物免疫系统的分子机制知之甚少。在这里，我们报告的晶体结构的效应域从两个卵菌RXLR蛋白，辣椒疫霉AVR 3a 11和致病疫霉PexRD 2。尽管共享
Phytopathogens deliver effector proteins inside host plant cells to promote infection. These proteins can also be sensed by the plant immune system, leading to restriction of pathogen growth. Effector genes can display signatures of positive selection and rapid evolution, presumably a consequence of their co-evolutionary arms race with plants. The molecular mechanisms underlying how effectors evolve to gain new virulence functions and/or evade the plant immune system are poorly understood. Here, we report the crystal structures of the effector domains from two oomycete RXLR proteins, Phytophthora capsici AVR3a11 and Phytophthora infestans PexRD2. Despite sharing