Origin of myofibroblasts in liver fibrosis.
Origin of myofibroblasts in liver fibrosis.
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DOI：
10.1186/1755-1536-5-s1-s17
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Taura K
中科院分区：
文献类型：
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作者：
Brenner DA;Kisseleva T;Scholten D;Paik YH;Iwaisako K;Inokuchi S;Schnabl B;Seki E;De Minicis S;Oesterreicher C;Taura K
所有病因的大多数慢性肝病都会导致进行性肝纤维化。肌成纤维细胞产生细胞外基质，包括I型胶原，其构成肝纤维化中的纤维瘢痕。正常肝脏几乎没有I型胶原，也没有可检测到的肌成纤维细胞，但肌成纤维细胞在实验和临床肝损伤中出现较早。肝纤维化中肌成纤维细胞的起源至今尚未明确。这些可能性包括激活内源性间充质细胞，包括成纤维细胞和肝星状细胞，从骨髓中募集，以及上皮细胞或内皮细胞转化为肌成纤维细胞。事实上，对于不同类型的慢性肝病，如胆汁淤积性肝病或肝毒性肝病，肌成纤维细胞的起源可能不同。本文将探讨我们目前对肝肌成纤维细胞的认识。
Most chronic liver diseases of all etiologies result in progressive liver fibrosis. Myofibroblasts produce the extracellular matrix, including type I collagen, which constitutes the fibrous scar in liver fibrosis. Normal liver has little type I collagen and no detectable myofibroblasts, but myofibroblasts appear early in experimental and clinical liver injury. The origin of the myofibroblast in liver fibrosis is still unresolved. The possibilities include activation of endogenous mesenchymal cells including fibroblasts and hepatic stellate cells, recruitment from the bone marrow, and transformation of epithelial or endothelial cells to myofibroblasts. In fact, the origin of myofibroblasts may be different for different types of chronic liver diseases, such as cholestatic liver disease or hepatotoxic liver disease. This review will examine our current understanding of the liver myofibroblast.