Defining a role for ambient TLR ligand exposures in the genesis and prevention of allergic diseases.
Defining a role for ambient TLR ligand exposures in the genesis and prevention of allergic diseases.
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定义环境 TLR 配体暴露在过敏性疾病发生和预防中的作用。
DOI：
10.1007/s00281-007-0098-8
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发表时间：
2008
影响因子：
9
通讯作者：
Horner,AnthonyA
中科院分区：
文献类型：
--
作者：
Tse,Kevin;Horner,AnthonyA
上个世纪在发达国家观察到的导致过敏性疾病负担增加的环境变量尚未得到充分的表征。本文前半部分介绍的流行病学研究的荟萃分析表明，与农场相关的暴露(即牲畜、宠物、未经巴氏灭菌的牛奶和内毒素)与儿童时期过敏风险的降低之间存在相关性。本论文后半部分讨论的实验室调查描述了生活环境中固有的免疫刺激活性。综合考虑，这里提出的实验结果提出了一种新的范式，通过该范式，早期家庭暴露于微生物产品和其他非特异性过敏原免疫刺激剂可以改变过敏风险。
Environmental variables responsible for the increasing allergic disease burden observed in developed countries over the last century have yet to be adequately characterized. Meta-analyses of epidemiological studies presented in the first half of this paper demonstrate a correlation between farm-associated exposures (i.e., livestock, pets, unpasteurized milk, and endotoxin) and a reduction in allergic risk during childhood. Laboratory investigations discussed in the second half of the paper characterize the intrinsic immunostimulatory activities of living environments. Considered together, experimental findings presented herein suggest a novel paradigm by which early life home exposures to microbial products and other allergen-nonspecific immunostimulants modify allergic risk.