RAPID REMODELING OF AXONAL ARBORS IN THE VISUAL-CORTEX
RAPID REMODELING OF AXONAL ARBORS IN THE VISUAL-CORTEX
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DOI：
10.1126/science.8511592
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发表时间：
1993-06-18
期刊：
影响因子：
56.9
通讯作者：
STRYKER, MP
中科院分区：
文献类型：
--
作者：
ANTONINI, A;STRYKER, MP
如果在出生后发育的关键时期，一只眼睛的视力模糊或闭塞，视觉皮层的神经元在几天内就会失去对通过这只眼睛的刺激的反应。在此之前，只有在数周的剥夺后，才观察到向视觉皮层提供输入的神经末梢的解剖变化，这表明突触在其所在的分支被撤回之前就会在生理上失效。重建单基因皮层轴突在猫短暂或长时间的单眼遮挡后，在两种情况下都显示出惊人的轴突重排。剥夺眼的分支迅速撤出表明轴突分支承载突触对神经元活动模式的变化反应迅速。
If vision in one eye is blurred or occluded during a critical period in postnatal development, neurons in the visual cortex lose their responses to stimulation through that eye within a few days. Anatomical changes in the nerve terminals that provide input to the visual cortex have previously been observed only after weeks of deprivation, suggesting that synapses become physiologically ineffective before the branches on which they sit are withdrawn. Reconstruction of single geniculocortical axonal arbors in the cat after either brief or prolonged monocular occlusion revealed striking axonal rearrangements in both instances. Rapid withdrawal of the branches of deprived-eye arbors suggests that axonal branches bearing synapses respond quickly to changing patterns of neuronal activity.