Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology
Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology
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DOI：
10.1093/eurheartj/ehr204
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发表时间：
2011-08-01
影响因子：
39.3
通讯作者：
Collet, Jean-Philippe
中科院分区：
文献类型：
--
作者：
Steg, Philippe Gabriel;Huber, Kurt;Collet, Jean-Philippe
出血最近已成为急性冠状动脉综合征（ACS）管理中的一个重要结局，与缺血性结局相比，出血相对常见，并且在预后、结局和成本方面具有重要意义。特别是，有证据表明，在急性期发生大出血的患者在随后的几个月内死亡的风险更高，尽管这种关系的因果性质仍有争议。本立场文件旨在总结ACS和经皮冠状动脉介入治疗中出血流行病学的现有知识，包括出血的测量和定义，重点是最近达成共识的出血学术研究联盟（BARC）定义。它还提供了一个欧洲的管理策略，以尽量减少出血的速度，程度和后果的观点。最后，还讨论了出血的研究意义（在试验中测量和报告出血，出血作为结局指标的重要性，以及出血作为未来研究的主题）。
Bleeding has recently emerged as an important outcome in the management of acute coronary syndromes (ACS), which is relatively frequent compared with ischaemic outcomes and has important implications in terms of prognosis, outcomes, and costs. In particular, there is evidence that patients experiencing major bleeding in the acute phase are at higher risk for death in the following months, although the causal nature of this relation is still debated. This position paper aims to summarize current knowledge regarding the epidemiology of bleeding in ACS and percutaneous coronary intervention, including measurement and definitions of bleeding, with emphasis on the recent consensus Bleeding Academic Research Consortium (BARC) definitions. It also provides an European perspective on management strategies to minimize the rate, extent, and consequences of bleeding. Finally, the research implications of bleeding (measuring and reporting bleeding in trials, the importance of bleeding as an outcome measure, and bleeding as a subject for future research) are also discussed.