CELLULAR MEDIATORS SECRETED BY INTERFACIAL MEMBRANES OBTAINED AT REVISION TOTAL HIP-ARTHROPLASTY
CELLULAR MEDIATORS SECRETED BY INTERFACIAL MEMBRANES OBTAINED AT REVISION TOTAL HIP-ARTHROPLASTY
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DOI：
10.1016/s0883-5403(05)80152-4
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发表时间：
1995-08-01
影响因子：
3.5
通讯作者：
GLANT, TT
中科院分区：
文献类型：
--
作者：
SHANBHAG, AS;JACOBS, JJ;GLANT, TT
在无菌松动的全髋关节置换术中，植入物和宿主骨之间的界面膜在局部骨吸收和假体部件松动的病因学中具有潜在的作用。测量了松动的非骨水泥型和骨水泥型全髋关节置换术的界面膜细胞释放的炎症/潜在“骨吸收”因子（细胞因子/介质）。来自急性股骨颈骨折患者、骨关节炎患者和无关节疾病的尸体的滑膜组织用作对照受试者。骨关节炎患者的对照滑膜组织分泌的前列腺素E2、白细胞介素8和肿瘤坏死因子α水平最高。白细胞介素-1 α是唯一一种细胞因子，其水平在非骨水泥型植入物周围比骨水泥型植入物高4倍，与对照滑膜组织相比高16倍。与对照滑膜组织相比，全髋关节置换术的白细胞介素-1 α和白细胞介素-6界面膜之间存在明显的反比关系，表明通过细胞因子/前列腺素级联反应的复杂细胞机制;这可能调节无菌性松动中观察到的骨吸收。
The interfacial membrane between implant and host-bone in aseptically loose total hip arthroplasties has a potential role in the etiology of local bone resorption and loosening of the prosthetic component. Inflammatory/potential ''bone-resorbing'' agents (cytokines/mediators) released by the cells of the interfacial membranes of loosened uncemented and cemented total hip arthroplasties were measured. Synovial tissues from patients with acute femoral neck fractures, patients with osteoarthritis, and cadavers without joint disorders were used as control subjects. Control synovial tissue from osteoarthritic patients secreted the highest levels of prostaglandin E(2), interleukin-8, and tumor necrosis factor alpha. Interleukin-1 alpha was the only cytokine whose levels were elevated as much as 4-fold around uncemented implants compared with cemented implants, and up to 16-fold compared with control synovial tissue. An apparent inverse relation between interleukin-1 alpha and interleukin-6 interfacial membranes of total hip arthroplasties compared with control synovial tissues suggests a complex cellular mechanism through a cytokine/prostaglandin cascade; this may regulate the observed bone resorption in aseptic loosening.