Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?
Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?
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DOI：
10.2174/1381612811319300007
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发表时间：
2013-09-01
影响因子：
3.1
通讯作者：
Della Ragione, Fulvio
中科院分区：
文献类型：
--
作者：
Borriello, Adriana;Bencivenga, Debora;Della Ragione, Fulvio
植物产生许多具有生物活性的低分子量天然化合物。其中，白藜芦醇（3,5,4'-三羟基二苯乙烯）已被证明能够影响多种关键的细胞分子过程，包括转导途径和基因表达。这些活动反过来导致几种不同的细胞表型。特别是，白藜芦醇治疗的常见效果似乎是生长减少和程序性细胞死亡的激活。因此，目前正在开发许多试验来评估在癌症治疗中使用白藜芦醇的可能性，无论是作为单一药物还是与其他抗癌化合物联合使用。然而，一些报告表明，在低浓度下，白藜芦醇不仅不会抑制细胞的增殖和/或存活，相反，它还会诱导增殖和/或保护细胞免受有毒物质的侵害。基于这些双相效应，有人提出白藜芦醇属于所谓的毒物兴奋效应化合物。毒物兴奋效应是毒理学家用来描述 U 形（或 J 形）剂量反应的一种表达方式，其特征是在低剂量时具有有益作用，在高剂量时具有毒性（或抑制）活性。在本次综述中，我们将重新评估可能表明或反驳白藜芦醇具有明显毒物兴奋特性的数据。
Plants produce many low molecular mass natural compounds endowed with biological activity. Among them, resveratrol (3,5,4'-trihydroxystilbene) has been demonstrated to be able to affect a plethora of pivotal cellular molecular processes, including transduction pathways and gene expression. These activities result, in turn, in several different cell phenotypes. Particularly, frequent effects of resveratrol treatment appear to be the reduction of growth and the activation of programmed cell death. Accordingly, a number of trials are currently under development to evaluate the possibility of using resveratrol in cancer therapy, both as single agent or in association with other anticancer compounds. However, some reports suggest that, at low concentrations, not only resveratrol does not inhibit the proliferation and/or the survival of cells but, conversely, it induces proliferation and/or protects cells against toxic agents. On the basis of these biphasic effects, it has been proposed that resveratrol belongs to the so-called hormetic compounds.Hormesis is an expression employed by toxicologists to describe a U-shaped (or J-shaped) dose response characterized by a beneficial effect at low doses and a toxic (or inhibitory) activity at high dose. In this review, we will reappraise data that might suggest or disprove that resveratrol is endowed with clear hormetic properties.