Shift work and the risk of diabetes mellitus among Japanese male factory workers
Shift work and the risk of diabetes mellitus among Japanese male factory workers
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DOI：
10.5271/sjweh.867
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发表时间：
2005-06-01
影响因子：
6.3
通讯作者：
Nogawa, K
中科院分区：
文献类型：
--
作者：
Morikawa, Y;Nakagawa, H;Nogawa, K
目的探讨轮班工作是否是糖尿病发生的危险因素。方法对日本富山县某肩带拉链厂2860名工人进行8年随访，测定其糖尿病发病率。这个群体包括固定的日间蓝领工人、轮班蓝领工人和白领工人。如果工人在年度健康检查中糖化血红蛋白水平为>= 6.1，或者由医院医生作出诊断，则认为他们患有糖尿病。采用Cox比例风险回归模型估计相对风险。结果2860名工人中，新发糖尿病87例，发病率为4.41 / 1000人年。年龄调整后的发病率在两班制工人中最高，在白领工人中最低。各混杂因素校正后，两班倒和三班倒工人与固定白班工人相比糖尿病的相对危险度分别为1.73和1.33，但差异无统计学意义。当以白领为参照组时，两班倒工人患糖尿病的风险显著增加（校正所有混杂因素后的相对风险为2.01），而三班倒工人和固定白天的蓝领工人患糖尿病的风险则显著增加。结论倒班工作是糖尿病发病的危险因素之一，不同的倒班时间有不同的发病风险。
Objectives This study investigated whether shift work is a risk factor for the development of diabetes mellitus.Methods The workers, 2860 men in a sash and zipper factory in the Toyama prefecture of Japan, were followed for 8 years, and the incidence rate of diabetes mellitus was determined. The cohort contained fixed daytime bluecollar workers, shift blue-collar workers, and white-collar workers. The workers were considered to have diabetes mellitus if, in their annual health examination, they had a glycated hemoglobin level of >= 6.1 or if the diagnosis had been made by a hospital physician. The relative risks were estimated by Cox's proportional hazards regression model.Results Among the 2860 workers, there were 87 cases of new-onset diabetes mellitus, resulting in an incidence rate of 4.41 per 1000 person-years. The age-adjusted incidence was highest for the two-shift workers and lowest for the white-collar workers. The relative risk of diabetes mellitus for the two-shift workers and the three-shift workers compared with the fixed daytime workers was 1.73 and 1.33, respectively, after adjustment for all the confounding factors, but these values were not statistically significant. When the white-collar workers were used as a reference group, a significantly increased risk of diabetes mellitus was found for the two-shift workers (relative risk was 2.01 after adjustment for all confounding factors), but not for the three-shift workers or the fixed daytime blue-collar workers.Conclusions The study suggests that shift work is a risk factor for the onset of diabetes mellitus and that there is a different risk associated with different shift schedules.