Human exposure to acrolein: Time -dependence and individual variation in eye irritation
Human exposure to acrolein: Time -dependence and individual variation in eye irritation
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DOI：
10.1016/j.etap.2016.05.011
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发表时间：
2016-07-01
影响因子：
4.3
通讯作者：
Lind, Nina
中科院分区：
文献类型：
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作者：
Claeson, Anna-Sara;Lind, Nina
该研究的目的是检查人类暴露于阈值水平的丙烯醛后对感觉刺激检测的时间依赖性。暴露发生在暴露室中，受试者通过覆盖鼻子和嘴巴的面罩呼吸新鲜空气。所有参与者都参与了四种暴露条件，其中三种由丙烯醛和庚烷的混合物组成，一种仅由庚烷组成。接触浓度为 TLV-C 一半的丙烯醛会导致感觉刺激。 58% 的参与者在暴露约 6.8 分钟后，感知到的感官刺激导致可检测性和感官刺激增加。该研究证实了先前建议的因丙烯醛暴露导致眼睛刺激的 LOAEL 约为 0.34mg/m(3)。接触后 10 分钟，感觉刺激仍然很明显。这些结果对职业卫生的风险评估和限值设定具有影响。 (c) 2016 Elsevier B.V. 保留所有权利。
The aim of the study was to examine the time dependence on sensory irritation detection following exposure to threshold levels of acrolein, in humans. The exposures occurred in an exposure chamber and the subjects were breathing fresh air through a mask that covered the nose and mouth. All participants participated in four exposure conditions, of which three consisted of a mixture of acrolein and heptane and one of only heptane. Exposure to acrolein at a concentration half of the TLV-C lead to sensory irritation. The perceived sensory irritation resulted in both increased detectability and sensory irritation after about 6.8 min of exposure in 58% of the participants. The study confirm the previously suggested LOAEL of about 0.34mg/m(3) for eye irritation due to acrolein exposure. The sensory irritation was still significant 10 min after exposure. These results have implications for risk assessment and limit setting in occupational hygiene. (c) 2016 Elsevier B.V. All rights reserved.