Fatty acid concentrations in patients with posttraumatic stress disorder compared to healthy controls
Fatty acid concentrations in patients with posttraumatic stress disorder compared to healthy controls
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DOI：
10.1016/j.jad.2016.08.021
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发表时间：
2016-11-15
影响因子：
6.6
通讯作者：
Olff, Miranda
中科院分区：
文献类型：
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作者：
de Vries, Giel-Jan;Mocking, Roel;Olff, Miranda
背景资料：虽然脂肪酸（FA）补充剂的研究目前正在实施中，事实上很少有人知道创伤后应激障碍（PTSD）的FA配置文件。因此，本研究旨在比较创伤后应激障碍患者和健康对照者之间的FA浓度。方法：一项横断面研究，比较了49名平民创伤所致创伤后应激障碍患者的混合性别样本和46名健康对照者的红细胞FA，包括二十二碳六烯酸（DHA）、二十碳五烯酸（EPA）、花生四烯酸（AA）和神经酸（NA）。在调整社会人口统计学和饮食因素后，PTSD患者的DHA显著低于对照组（p = 0.043）。此外，探索性分析显示PTSD患者的异油酸（p = 0.035）和二十碳三烯酸（p = 0.006）较低，但芥酸（p = 0.032）较高。在调整社会人口因素后，芥酸的作用仍然存在（p = 0.047）;在额外调整饮食因素后，发现这些FA均不显著。局限性：统计能力的差异与小的影响大小是有限的，饮食评估可以优化。结论：我们发现很少的证据FA代谢在PTSD中的相当大的作用。除了调整混杂因素后DHA较低外，在假设的长链多不饱和FA浓度中没有观察到差异。此外，我们发现在长链单不饱和脂肪酸，这可能是由饮食因素解释的变化很少。然而，观察到的小的影响大小和有限的程度的改变强调了进一步调查FA代谢的假设作用及其在PTSD中的潜在机制的重要性，在实施进一步的FA补充研究之前。(C)2016爱思唯尔B. V.保留所有权利。
Background: Although fatty acid (FA)-supplementation studies are currently being implemented, in fact little is known about FA-profiles in posttraumatic stress disorder (PTSD). Therefore, the present study aimed at comparing FA-concentrations between PTSD-patients and healthy controls.Methods: A cross-sectional study comparing a mixed-gender sample of 49 patients with PTSD due to civilian trauma to 46 healthy controls regarding erythrocyte FAs including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), arachidonic acid (AA), and nervonic acid (NA).Results: DHA was found to be significantly lower in PTSD-patients compared to controls after adjusting for sociodemographic and dietary factors (p = 0.043). Additionally, exploratory analyses showed lower vaccenic acid (p = 0.035) and eicosatrienoic acid (p = 0.006), but higher erucic acid (p = 0.032) in PTSD-patients. The effect of erucic acid remained after adjustment for sociodemographic factors (p = 0.047); with the additional adjustment for dietary factors none of these FAs were found to be significant. Limitations: Statistical power for differences with small effect sizes was limited, and dietary assessment could be optimized.Conclusions: We found little evidence for a considerable role of FA-metabolism in PTSD. Apart from lower DHA after adjusting for confounders, no differences were observed in the hypothesized long-chained polyunsaturated FA-concentrations. Additionally, we found few alterations in the long-chained mono-unsaturated FAs, which may be explained by dietary factors. Nevertheless, the observed small effect sizes and limited extent of the alterations emphasize the importance of further investigating the assumed role of FA-metabolism and its underlying mechanisms in PTSD, before implementing further FA-supplementation studies. (C) 2016 Elsevier B.V. All rights reserved.