Antimicrobial Activity of Zinc Oxide-Graphene Quantum Dot Nanocomposites: Enhanced Adsorption on Bacterial Cells by Cationic Capping Polymers
Antimicrobial Activity of Zinc Oxide-Graphene Quantum Dot Nanocomposites: Enhanced Adsorption on Bacterial Cells by Cationic Capping Polymers
复制标题
氧化锌-石墨烯量子点纳米复合材料的抗菌活性：阳离子封端聚合物增强对细菌细胞的吸附
DOI：
10.1021/acssuschemeng.9b03292
复制
发表时间：
2019-10-07
影响因子：
8.4
通讯作者：
Chen, Shaowei
中科院分区：
文献类型：
--
作者：
Liu, Junli;Shao, Jianzhen;Chen, Shaowei
面对越来越多的细菌对常规抗生素的耐药性，开发低成本、高性能的抗菌试剂至关重要。本研究采用溶胶-凝胶法制备了聚乙烯亚胺修饰的石墨烯量子点（GQD）和氧化锌纳米粒子复合材料，与不含PEI的氧化锌/GQD相比，它们易于分散在水中，对大肠杆菌的抗菌活性显著增强。这在很大程度上归因于纳米颗粒尺寸的减小和纳米复合材料在细菌细胞表面的吸附增强，吸附实验、细菌细胞的TEM表征以及电子自旋共振测量都证明了这一点。这一结果凸显了功能纳米复合材料结构工程在高效抗菌剂开发中的重要意义。
Development of low-cost, high-performance antibacterial reagents is of critical importance in the face of increasing occurrence of bacterial resistance against conventional antibiotics. In the present study, polyethylenimine (PEI)-modified graphene quantum dot (GQD) and ZnO nanoparticle nanocomposites, which were readily dispersed in water and exhibited markedly enhanced antimicrobial activity toward Escherichia coli, as compared to the PEI-free ZnO/GQD counterparts, were prepared by a facile sol gel method. This was largely ascribed to the reduced size of the nanoparticles and the enhanced adsorption of the nano composites onto the bacterial cell surfaces, as manifested by adsorption experiments and TEM characterization of the bacterial cells, as well as electron spin resonance measurements. The results highlight the significance of structural engineering of functional nanocomposites in the development of efficient antibacterial agents.