Genetic control of bacterial biofilms.
Genetic control of bacterial biofilms.
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DOI：
10.1007/s13353-015-0309-2
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发表时间：
2016-05
影响因子：
2.4
通讯作者：
Markowska K
中科院分区：
文献类型：
--
作者：
Wolska KI;Grudniak AM;Rudnicka Z;Markowska K
几乎所有的细菌物种，包括病原体，都有形成生物膜的能力。生物膜被定义为结构化的生态系统，其中微生物附着于表面并嵌入由多糖、eDNA和蛋白质组成的基质中，并且它们的发展是一个多步骤的过程。细菌生物膜由于其对各种类型的治疗剂（包括常规抗生素）的极高抗性而构成大的医学问题。一些环境和遗传信号控制生物膜发展和扩散的每一步。在后者中，群体感应、环二鸟苷-5 '-单磷酸和小RNA被认为是主要的调节剂。本文综述了这三种调节剂在铜绿假单胞菌、金黄色葡萄球菌、鼠伤寒沙门氏菌和霍乱弧菌生物膜生命周期中的控制作用。他们的活动之间的相互联系显示。化合物和策略的目标，这些监管机构的活动，主要是群体感应抑制剂，其在治疗中的潜在作用也进行了评估。
Nearly all bacterial species, including pathogens, have the ability to form biofilms. Biofilms are defined as structured ecosystems in which microbes are attached to surfaces and embedded in a matrix composed of polysaccharides, eDNA, and proteins, and their development is a multistep process. Bacterial biofilms constitute a large medical problem due to their extremely high resistance to various types of therapeutics, including conventional antibiotics. Several environmental and genetic signals control every step of biofilm development and dispersal. From among the latter, quorum sensing, cyclic diguanosine-5’-monophosphate, and small RNAs are considered as the main regulators. The present review describes the control role of these three regulators in the life cycles of biofilms built by Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella enterica serovar Typhimurium, and Vibrio cholerae. The interconnections between their activities are shown. Compounds and strategies which target the activity of these regulators, mainly quorum sensing inhibitors, and their potential role in therapy are also assessed.