Ultrathin gradient films using thiol-ene polymerizations
Ultrathin gradient films using thiol-ene polymerizations
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DOI：
10.1002/pola.21786
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发表时间：
2006-12-15
影响因子：
--
通讯作者：
Bowman, Christopher N.
中科院分区：
文献类型：
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作者：
Khire, Vaibhav S.;Benoit, Danielle S. W.;Bowman, Christopher N.
研究了表面附着的硫醇-烯聚合物膜在整个表面上以梯度方式控制材料性质的应用。通过首先沉积硫醇封端的自组装单层并在表面上进行硫醇-烯光聚合反应，将硫醇-烯膜附着到表面。通过在SAM中产生和改变表面硫醇密度的梯度或通过改变聚合条件或两者来产生性质梯度。通过改变锚定硫醇官能团的密度或通过改变反应条件如暴露时间来改变整个基底上的膜厚度。较厚的膜（1-11 nm）通过用不同的暴露时间（0-60 s）从表面聚合丙烯酸酯聚合物刷来获得。两个因素，即，表面硫醇密度和曝光时间，在正交方向相结合，得到的硫醇-烯膜的二维厚度梯度的最大厚度为4 nm。最后，使用硫醇-丙烯酸酯迈克尔型加成反应来用细胞粘附配体Arg-Gly-Asp-Ser（RGDS）修饰表面硫醇密度梯度，其随后在表面上产生成骨细胞密度梯度。(c)2006 Wiley Periodicals，Inc.
The application of surface-attached, thiol-ene polymer films for controlling material properties in a gradient fashion across a surface was investigated. Thiol-ene films were attached to the surface by first depositing a thiol-terminated self-assembled monolayer and performing a thiol-ene photopolymerization reaction on the surface. Property gradients were created either by creating and modifying a gradient in the surface thiol density in the SAM or by changing the polymerization conditions or both. Film thickness was modified across the substrate by changing either the density of the anchoring thiol functional groups or by changing the reaction conditions such as exposure time. Thicker films (1-11 nm) were obtained by polymerizing acrylate polymer brushes from the surface with varying exposure time (0-60 s). The two factors, that is, the surface thiol density and the exposure time, were combined in orthogonal directions to obtain thiol-ene films with a two-dimensional thickness gradient with the maximum thickness being 4 nm. Finally, a thiol-acrylate Michael type addition reaction was used to modify the surface thiol density gradient with the cell-adhesive ligand, Arg-Gly-Asp-Ser (RGDS), which subsequently yielded a gradient in osteoblast density on the surface. (c) 2006 Wiley Periodicals, Inc.