Cerebral perfusion and neuropsychological consequences of chronic cocaine use.
Cerebral perfusion and neuropsychological consequences of chronic cocaine use.
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长期使用可卡因的脑灌注和神经心理学后果。
DOI：
10.1176/jnp.5.4.419
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Myers,H
中科院分区：
文献类型：
--
作者：
Strickland,TL;Mena,I;Villanueva-Meyer,J;Miller,BL;Cummings,J;Mehringer,CM;Satz,P;Myers,H
研究表明，可卡因显著收缩脑血管，可导致缺血性脑梗死。研究了间歇或偶然使用可卡因对没有中风或短暂性脑缺血发作症状的患者的长期影响。使用氙-133和[99 mTc]六甲基丙二胺肟的单光子发射计算机断层扫描、磁共振成像和选定的神经心理学测量方法来研究脑灌注、脑形态和认知功能。患者在评估前至少6个月无药物。所有患者均显示额叶、脑室周围和/或颞顶叶区域存在显著脑灌注不足。缺陷的注意力，浓度，新的学习，视觉和文字记忆，文字的生产，和视觉整合。这项研究表明，长期使用可卡因可能会产生持续的脑灌注不足和持续的神经心理损害的可卡因滥用患者的一些亚组。
Research indicates that cocaine significantly constricts the cerebral vasculature and can lead to ischemic brain infarction. Long-term effects of intermittent or casual cocaine use in patients without symptoms of stroke or transient ischemic attack were investigated. Single-photon emission computed tomography with xenon-133 and [99mTc] hexamethylpropyleneamine oxime, magnetic resonance imaging, and selected neuropsychological measures were used to study cerebral perfusion, brain morphology, and cognitive functioning. Patients were drug free for at least 6 months before evaluation. All showed regions of significant cerebral hypoperfusion in the frontal, periventricular, and/or temporal-parietal areas. Deficits in attention, concentration, new learning, visual and verbal memory, word production, and visuomotor integration were observed. This study indicates that long-term cocaine use may produce sustained brain perfusion deficits and persistent neuropsychological compromise in some subgroups of cocaine-abusing patients.