A rapid and reliable size-exclusion chromatographic method for determination of kojic dipalmitate in skin-whitening cosmetic products
A rapid and reliable size-exclusion chromatographic method for determination of kojic dipalmitate in skin-whitening cosmetic products
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DOI：
10.1016/j.talanta.2007.11.021
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发表时间：
2008-04-15
期刊：
影响因子：
6.1
通讯作者：
Chisvert, Alberto
中科院分区：
文献类型：
--
作者：
Balaguer, Angel;Salvador, Amparo;Chisvert, Alberto
建立了测定美白化妆品中新型美白剂曲酸二棕榈酸酯（KDP）的体积排阻色谱法，对标准溶液和样品溶液的溶剂进行了初步试验，并且还用于移动的相组成。（聚苯乙烯/二乙烯基苯共聚物）柱和纯四氢呋喃的等度移动的流动相（在1.5 mL min（-1）流速下）。采用紫外-维斯分光光度法，检测波长为248 nm，对化妆品基质的干扰进行了研究，结果表明该方法不受化妆品基质的干扰。用该方法测定了6个自制和5个市售美白化妆品样品，结果表明，该方法的灵敏度和检出限（3 μ g mL ~（-1））均满足美白化妆品的分析要求。该方法操作简便，色谱分析时间小于8 min，适用于化妆品行业的质量控制。(c)2007 Elsevier B. V.保留所有权利。
A size-exclusion chromatographic method has been developed to determine the relatively novel skin-whitening agent called kojic dipalmitate (KDP) in skin-whitening cosmetic products.Preliminary experiments were carried out in order to select the solvent for standard and sample solution, and also for mobile phase composition.A PLGel Mixed-D (polystyrene/divinylbenzene co-polymer) column and isocratic mobile phase of pure tetrahydrofuran (at 1.5 rnL min(-1) flow rate) were used. Detection was carried out by means of an UV/vis spectrometry detector set at 248 nm.A study of interferences reveals that KDP can be determined without interferences coming from cosmetic matrices. Most other cosmetic ingredients usually employed in skin-whitening cosmetic products, such as other whitening agents and common UV filters, do not interfere.The accuracy and precision of the proposed method was tested by the analysis of six laboratory-made and five commercial skin-whitening cosmetic samples.The sensitivity and limit of detection (3 mu g mL(-1)) obtained are suitable for the analysis of this type of samples. The chromatographic run takes less than 8 min to complete.All these features make the method easy to apply to quality control in the cosmetic industry. (c) 2007 Elsevier B.V. All rights reserved.