Genetically engineered mouse models of melanoma.
Genetically engineered mouse models of melanoma.
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DOI：
10.1002/cncr.30684
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发表时间：
2017-06-01
期刊：
影响因子：
6.2
通讯作者：
Zaidi MR
中科院分区：
文献类型：
--
作者：
Pérez-Guijarro E;Day CP;Merlino G;Zaidi MR
黑色素瘤是一种复杂的疾病，表现出高度异质性的病因学，组织病理学，遗传学特征，以及治疗反应。基因工程小鼠（GEM）模型提供了强大的工具，以解开黑色素瘤的发展和耐药性的分子机制至关重要。本文简要阐述了小鼠模型设计的基础、现有的基因工程技术以及影响GEM用于黑色素瘤模型的因素。此外，我们详细描述了目前可用的GEM模型的黑色素瘤。
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma.