PRODUCTION OF ANOVULATORY, STERILE RATS BY SINGLE INJECTIONS OF TESTOSTERONE PROPIONATE
PRODUCTION OF ANOVULATORY, STERILE RATS BY SINGLE INJECTIONS OF TESTOSTERONE PROPIONATE
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DOI：
10.1210/endo-68-1-62
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发表时间：
1961-01-01
期刊：
影响因子：
4.8
通讯作者：
BARRACLOUGH, C
中科院分区：
文献类型：
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作者：
BARRACLOUGH, C
目前的调查研究的影响，一个单一的注射雄激素在青春期前的雌性大鼠的内分泌系统的后续发展。单次皮下注射1.25 mg。将丙酸睾酮给予2、5、10或20日龄的雌性大鼠。让动物成熟至100日龄，然后进行尸检或生育力测试。尸检时，2或5日龄给药大鼠的肾上腺和垂体重量显著大于同窝对照组。在10或20日龄接受治疗的大鼠中未观察到肾上腺、垂体或子宫重量差异。在2或5日龄时注射的动物中，卵巢和子宫重量明显较小，但在20日龄时给药的动物中并非如此。10天注射组处于中间位置。在100日龄尸检时，2天和5日龄注射组的卵巢以及10日龄给药的10只大鼠中的4只大鼠的卵巢中不存在黄体。繁殖研究表明，在2或5日龄时给予雄激素可诱导所有动物永久性不育，在10日龄时给予雄激素的10只大鼠中有4只永久性不育。20日龄时注射的所有动物产下正常窝仔。从这些实验中可以看出，从出生到10天龄之间存在一个雄激素敏感期。
The current investigation studies the effect of a single injection of androgen in the prepubertal female rat on subsequent development of the endocrine system. A single subcutaneous injection of 1.25 mg. of testosterone propionate was administered to 2, 5, 10 or 20 day-old female rats. The animals were allowed to mature to 100 days of age and then were either autopsied or tested for fertility. At autopsy, adrenal and pituitary weights were significantly larger than littermate controls in rats treated at 2 or 5 days of age. No difference in adrenal, pituitary or uterine weight was observed in rats treated at 10 or 20 days of age. Ovarian and uterine weights were markedly smaller in animals injected at 2 or 5 days of age, but not in animals treated at 20 days of age. The 10 day injected group assumed an intermediate position. Corpora lutea were absent from the ovaries of the 2 and 5 day injected groups and from 4 of 10 rats treated at 10 days of age when autopsied at 100 days of age. Breeding studies revealed that administration of androgen at 2 or 5 days of age induced permanent sterility in all animals and in 4 of 10 rats treated at 10 days of age. All animals injected at 20 days of age bore normal litters. It is suggested from these experiments that an androgen-sensitive period exists between birth and the tenth day of age.