Lymph vessels: the forgotten second circulation in health and disease.
Lymph vessels: the forgotten second circulation in health and disease.
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DOI：
10.1007/s00428-016-1945-6
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Baandrup U
中科院分区：
文献类型：
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作者：
Adamczyk LA;Gordon K;Kholová I;Meijer-Jorna LB;Telinius N;Gallagher PJ;van der Wal AC;Baandrup U
淋巴循环仍然是一个有点被遗忘的循环系统的一部分。尽管如此，在健康和疾病中淋巴血管生成的新见解，淋巴生长和分化的免疫标记物的应用，以及引入新的成像技术来可视化淋巴循环，提高了我们对健康和疾病中淋巴功能的理解，特别是在过去十年中。这些成就使我们更好地了解淋巴水肿和畸形的各种表现，以及癌症的淋巴血管扩散模式。识别淋巴管内皮抗原的免疫标记物，如podoplanin，LYVE-1和Prox-1，可以成功地应用于诊断病理学，并揭示了（至少部分）在许多类型的血管病变的淋巴分化。本文的在线版本（doi：10.1007/s 00428 -016-1945-6）包含补充材料，可供授权用户使用。
The lymphatic circulation is still a somewhat forgotten part of the circulatory system. Despite this, novel insights in lymph angiogenesis in health and disease, application of immune markers for lymphatic growth and differentiation and also the introduction of new imaging techniques to visualize the lymphatic circulation have improved our understanding of lymphatic function in both health and disease, especially in the last decade. These achievements yield better understanding of the various manifestations of lymph oedemas and malformations, and also the patterns of lymphovascular spread of cancers. Immune markers that recognize lymphatic endothelium antigens, such as podoplanin, LYVE-1 and Prox-1, can be successfully applied in diagnostic pathology and have revealed (at least partial) lymphatic differentiation in many types of vascular lesions. The online version of this article (doi:10.1007/s00428-016-1945-6) contains supplementary material, which is available to authorized users.