QUERCETIN INHIBITS TYROSINE PHOSPHORYLATION BY THE CYCLIC NUCLEOTIDE-INDEPENDENT, TRANSFORMING PROTEIN-KINASE, PP60SRC
QUERCETIN INHIBITS TYROSINE PHOSPHORYLATION BY THE CYCLIC NUCLEOTIDE-INDEPENDENT, TRANSFORMING PROTEIN-KINASE, PP60SRC
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DOI：
10.1007/bf00506266
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发表时间：
1981-01-01
影响因子：
3.6
通讯作者：
EIGENBRODT, E
中科院分区：
文献类型：
--
作者：
GLOSSMANN, H;PRESEK, P;EIGENBRODT, E
槲皮素是一种非环核苷酸依赖性、[鸡]肿瘤[劳斯肉瘤]病毒编码的蛋白激酶的有效抑制剂，该蛋白激酶磷酸化酪氨酸残基并作为细胞转化蛋白。蛋白激酶的半数最大抑制发生在3-4 μ M槲皮素时;芦丁的有效性低得多。槲皮素抑制环核苷酸非依赖性蛋白激酶活性的发现可能为槲皮素的多种药理作用提供线索。
The bioflavonoid quercetin is a potent inhibitor of a cyclic nucleotide-independent, [chicken] tumor [Rous sarcoma] virus-coded protein kinase which phosphorylates tyrosine residues and acts as a cellular transforming protein. Half-maximal inhibition of the protein kinase occurred at 3-4 .mu.M quercetin; rutin was much less effective. The finding that quercetin inhibits a cyclic nucleotide-independent protein kinase activity may provide clues to the diverse pharmacological effects of the bioflavonoids.