Retinal autoregulation in open-angle glaucoma.
Retinal autoregulation in open-angle glaucoma.
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DOI：
10.1016/s0161-6420(84)34091-x
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发表时间：
1984-12
期刊：
影响因子：
13.7
通讯作者：
J. Grunwald;C. E. Riva;Richard A. Stone;Edwin U. Keates;B. Petrig
中科院分区：
文献类型：
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作者：
J. Grunwald;C. E. Riva;Richard A. Stone;Edwin U. Keates;B. Petrig
对11例开角型青光眼患者、8例可疑青光眼患者和13例正常志愿者进行了蓝视野正视现象的黄斑血流对眼压变化(自动调节)的研究。用吸盘将眼内压(IOP)升高至静息状态(IOPrest)以上。青光眼患者眼压最大值为24.9±1.5 mm Hg(±1SD)，可疑青光眼患者为30.8±4.6 mm Hg，正常人为29.9±3.6 mm Hg。IOPmax-IOPrest值分别为3.7±4.3、4.7±3.3、14.3±3.1 mm Hg。释放吸盘后，17只正常眼中有16只眼出现充血反应，14只可疑青光眼中有10只眼出现充血反应，19只青光眼只有9只眼出现充血反应。这些结果提示开角型青光眼患者存在黄斑视网膜血流的异常自动调节。
The macular blood flow response to an induced change in intraocular pressure (autoregulation) was studied using the blue field entopic phenomenon in 11 open angle glaucoma patients, eight glaucoma suspects and 13 normal volunteers. A suction cup was used to raise the intraocular pressure (IOP) above its resting state (IOPrest). IOPmax, the highest acutely increased IOP for which blood flow can be maintained constant by autoregulation, was 24.9 ± 1.5 mmHg (±1 SD) in the glaucoma patients, 30.8 ± 4.6 mmHg in the glaucoma suspects and 29.9 ± 3.6 mmHg in the normal subjects. The values for IOPmax- IOPrestwere 3.7 ± 4.3 mmHg, 4.7 ± 3.3 mmHg, and 14.3 ± 3.1 mmHg, respectively. After the release of the suction cup, a hyperemic response was observed by 16 of 17 normal eyes, 10 of 14 glaucoma suspect eyes and only 9 of 19 glaucomatous eyes. These results suggest an abnormal autoregulation of macular retinal blood flow in open-angle glaucoma.