UV-curable, 3D printable and biocompatible silicone elastomers
UV-curable, 3D printable and biocompatible silicone elastomers
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可紫外线固化、可 3D 打印且具有生物相容性的有机硅弹性体
DOI：
10.1016/j.porgcoat.2019.105372
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发表时间：
2019-12-01
影响因子：
6.6
通讯作者：
Liu, Xiaoxuan
中科院分区：
文献类型：
--
作者：
Xiang, Hongping;Wang, Xiaowei;Liu, Xiaoxuan
本研究探索了一种生物相容性有机硅弹性体，该弹性体可以通过乙烯基和硫醇官能化聚硅氧烷之间的硫醇-烯光聚合进行UV固化和3D打印。原位光流变学研究表明，硅橡胶在紫外光照射下瞬间发生光交联，胶凝时间受硫醇烯摩尔比、光引发剂用量和紫外光照射强度的协同影响。差示扫描量热仪结果表明，紫外光引发的硫醇-烯光反应符合二级反应动力学，其活化能约为23.3kJ/mol。此外，抗菌试验表明，硫醇烯型紫外光固化硅橡胶可抑制革兰氏阳性菌（S。aureus）和革兰氏阴性（E.细菌在一定程度上。细胞毒性和生物相容性研究结果表明，该硅橡胶也具有良好的生物相容性，用作伤口敷料有利于伤口的恢复。此外，由于硫醇-烯光反应具有良好的时空可控性，通过光图案化可以制造出各种复杂的结构。另一方面，这种UV固化配方也可以3D打印成各种结构，具有光滑的表面和良好的精度。这些结果表明，硫醇-烯UV固化硅橡胶将是一种有前途的材料，在生物医学应用中作为伤口敷料或通过3D打印定制的软组织支架。
A biocompatible silicone elastomer that can be UV-cured and 3D printed via thiol-ene photopolymerization between vinyl and thiol functionalized polysiloxanes is explored in this study. The in-situ photo-rheology demonstrates that the photo-crosslinking of silicone elastomer occurs instantaneously upon exposure to UV radiation and its gelation time is influenced synergically by thiol-ene molar ratio, photoinitiator dosage and UV irradiation intensity. Differential scanning photo-calorimeter results indicate that UV-initiated thiol-ene photoreaction preferably follows a second-order reaction kinetics and its activation energy is approximately 23.3 kJ/mol. Moreover, antibacterial assay shows thiol-ene UV-cured silicone elastomer can inhibit the growth of Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria to some extent. Cytotoxicity and biocompatibility results reveal that this silicone elastomer also has good biocompatibility, and it used as wound dressing is conducive to the recovery of wounds. Furthermore, due to excellent spatiotemporal controllability of thiol-ene photoreaction, various elaborate architectures are fabricated by photo-patterning. On the other hand, this UV-curable formulation can also be 3D printed into various structures with smooth surface and good accuracy. These results propose that thiol-ene UV-curable silicone elastomer will be a promising material in biomedical applications as wound dressings or customized soft tissue scaffolds through 3D printing.