PEDIATRIC CANCER IN THE UNITED-STATES - A PRELIMINARY-REPORT OF A COLLABORATIVE STUDY OF THE CHILDRENS CANCER GROUP AND THE PEDIATRIC ONCOLOGY GROUP
PEDIATRIC CANCER IN THE UNITED-STATES - A PRELIMINARY-REPORT OF A COLLABORATIVE STUDY OF THE CHILDRENS CANCER GROUP AND THE PEDIATRIC ONCOLOGY GROUP
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DOI：
10.1002/1097-0142(19930515)71:10
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发表时间：
1993-05-15
期刊：
影响因子：
6.2
通讯作者：
HAMMOND, GD
中科院分区：
文献类型：
--
作者：
ROSS, JA;SEVERSON, RK;HAMMOND, GD
背景。癌症是15岁以下儿童死亡的第二大原因。尽管许多儿童期肿瘤的5年生存率显著提高，但每年仍有超过10万人因儿童期癌症而失去生命。在采用最新治疗方案的中心（如儿童癌症组（CCG）或儿童肿瘤组（POG）附属中心）接受治疗的儿科癌症患者的确切比例尚不清楚。根据诊断时的居住地，将CCG和POG成员机构在1989年和1990年观察到的儿童癌症病例数与预期病例数进行比较。期望值是根据监测、流行病学和最终结果项目获得的发病率和美国人口普查局获得的人口计数计算得出的。结果表明，超过90%的15岁以下被诊断为恶性肿瘤的儿童都是在CCG或POG的成员机构中就诊的。以年龄最小（0-4岁）年龄组发病率最高，随着年龄的增长，发病率稳步下降。在美国的一些特定地区，观察到的病例数量大大低于预期数量，包括德克萨斯州的一些地区。爱达荷州和弗吉尼亚州。虽然这些潜在缺陷的确切原因尚不清楚，但建议对这些领域进行进一步研究。
Background. Cancer is the second leading cause of death in children younger than 15 years. Although 5-year survival rates have increased dramatically for many childhood tumors, more than 100,000 person-years of life are lost to childhood cancer each year. The exact proportion of pediatric patients with cancer who receive care at centers that use up-to-date therapeutic protocols (such as those affiliated with the Childrens Cancer Group (CCG) or the Pediatric Oncology Group (POG) is unknown.Methods. Based on residence at the time of diagnosis, observed numbers of pediatric cancer cases seen by member institutions of the CCG and the POG in 1989 and 1990 were compared with the expected number of cases. Expected values were calculated from incidence rates obtained from the Surveillance, Epidemiology, and End Results Program and population counts obtained from the US Census Bureau.Results. Results indicate that more than 90% of children younger than 15 years who have a diagnosis of malignant neoplasm are seen al an institution that is a member of either CCG or POG. The highest proportion seen occurs in the youngest (0-4 years) age group, and the proportion declines steadily with increasing age.Conclusions. There are specific regions within the United States where the observed number of cases was substantially less than the expected number, including areas of Texas. Idaho, and Virginia. Although the exact reasons for these potential deficits are unknown, additional study of these areas is recommended.