Action-based body maps in the spinal cord emerge from a transitory floating organization
Action-based body maps in the spinal cord emerge from a transitory floating organization
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DOI：
10.1523/jneurosci.0651-08.2008
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发表时间：
2008-05-21
影响因子：
5.3
通讯作者：
Schouenborg, Jens
中科院分区：
文献类型：
--
作者：
Granmo, Marcus;Petersson, Per;Schouenborg, Jens
在发育过程中，初级传入神经元生长到脊髓中并建立神经元连接，从而形成我们如何感知感觉信息和控制我们的动作的基础。在躯体感觉系统中，从不同的身体位置和感觉模式传递信息的无数初级传入被组织在脊髓的背角，从而使脊髓多感觉回路接收到按地形图顺序排列的信息。然而，这种错综复杂的探索是如何在发展过程中实现的，在很大程度上是未知的。在这里，我们展示了与运动模式密切相关的身体表征通过深刻的活动依赖的重新连接从短暂的浮动和可塑性组织中出现，涉及到传入连接的萌发和消除，并为多感觉输入对齐中的跨通道交互作用提供了证据。因此，脊髓的背角不是与生俱来的，也不是刻板印象的，现在看起来是一个高度适应性的脑体接口。
During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface.