Natural products for treating cytokine storm-related diseases: Therapeutic effects and mechanisms
Natural products for treating cytokine storm-related diseases: Therapeutic effects and mechanisms
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DOI：
10.1016/j.biopha.2023.115555
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发表时间：
2023-09-28
影响因子：
7.5
通讯作者：
Li，Xianyu
中科院分区：
文献类型：
--
作者：
Liu，Mei;Wang，Qing;Li，Xianyu
细胞因子风暴(CS)是由病原体和其他因素引起的一种快速、复杂、高致死性的全身性急性炎症反应。目前，尚无疗效显著、副作用小的临床治疗药物。鉴于CS的发病机制，天然产物已成为开发抗CS药物的重要资源。目的通过综述近年来发现的抑制CS的天然产物，为CS相关疾病的防治提供指导。方法利用PubMed和Web of Science等数据库，对CS及其天然产物进行综合文献综述。结果本研究总结了30多种天然产物，包括9类黄酮类、酚类和萜类化合物，体内外实验证明这些天然产物可通过核因子kappa-B、丝裂原活化蛋白激酶和哺乳动物雷帕霉素靶标(MTOR)信号通路有效地抑制CS。此外，酶抑制实验表明，有20多种化学成分具有抑制ACE2、3CL-蛋白水解酶和类木瓜蛋白酶活性的作用。结论中药提取物中的多种天然成分可直接或间接抑制CS的发生，有望成为治疗CS相关疾病的有效药物。本研究对进一步探讨天然产物对CS的治疗作用及生化机制具有指导意义。
BackgroundA cytokine storm (CS) is a rapidly occurring, complex, and highly lethal systemic acute inflammatory response induced by pathogens and other factors. Currently, no clinical therapeutic drugs are available with a significant effect and minimal side effects. Given the pathogenesis of CS, natural products have become important resources for bioactive agents in the discovery of anti-CS drugs.PurposeThis study aimed to provide guidance for preventing and treating CS-related diseases by reviewing the natural products identified to inhibit CS in recent years.MethodsA comprehensive literature review was conducted on CS and natural products, utilizing databases such as PubMed and Web of Science. The quality of the studies was evaluated and summarized for further analysis.ResultsThis study summarized more than 30 types of natural products, including 9 classes of flavonoids, phenols, and terpenoids, among others.In vivoand in vitro experiments demonstrated that these natural products could effectively inhibit CS via nuclear factor kappa-B, mitogen-activated protein kinase, and Mammalian target of rapamycin (mTOR) signaling pathways. Moreover, the enzyme inhibition assays revealed that more than 20 chemical components had the potential to inhibit ACE2, 3CL-protease, and papain-like protease activity. The experimental results were obtained using advanced technologies such as biochips and omics.ConclusionsVarious natural compounds in traditional Chinese medicine (TCM) extracts could directly or indirectly inhibit CS occurrence, potentially serving as effective drugs for treating CS-related diseases. This study may guide further exploration of the therapeutic effects and biochemical mechanisms of natural products on CS.