Should a third booster dose be scheduled after two doses of CoronaVac? A single-center experience
Should a third booster dose be scheduled after two doses of CoronaVac? A single-center experience
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DOI：
10.1002/jmv.27318
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发表时间：
2021-09-10
影响因子：
12.7
通讯作者：
Senel, Emrah
中科院分区：
文献类型：
--
作者：
Yigit, Metin;Ozkaya-Parlakay, Aslinur;Senel, Emrah
在疫情爆发的第10个月，在获得卫生部紧急使用批准后，土耳其首先为医护人员接种了2019冠状病毒病（COVID-19）疫苗。这项研究在安卡拉（土耳其首都）的COVID-19参考中心进行，旨在评估CoronaVac疫苗的血清转化率。回顾性研究了既往无严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染史的医护人员对两剂疫苗接种的抗刺突免疫球蛋白G反应。通过测量接种过CoronaVac的医护人员的抗体水平来调查疫苗后血清转换率。每隔28天接种600 SU。使用医护人员的抗SARS-CoV-2免疫球蛋白G水平来确定第二剂疫苗接种后2个月的血清转换率。在医护人员中，22.9%（n = 155）的血清反应呈阴性。参与者年龄越小，抗SARS-CoV-2免疫球蛋白G水平越高。此外，女性的抗SARS-CoV-2免疫球蛋白G水平远高于男性。
In the 10th month of the pandemic, coronavirus disease 2019 (COVID-19) vaccination was given first to healthcare workers in Turkey after receiving emergency use approval from the Ministry of Health. This study, which was performed at the COVID-19 reference center in Ankara (the capital of Turkey) aimed to evaluate the seroconversion rate of the CoronaVac vaccine. The anti-spike immunoglobulin G response to the two-dose vaccination was retrospectively examined in healthcare workers who had no previous history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The postvaccine seroconversion rate was investigated by measuring the antibody levels of healthcare workers who had received CoronaVac. Vaccination was administered as 600 SU in 28-day intervals. The healthcare workers' anti-SARS-CoV-2 immunoglobulin G levels were used to determine the seroconversion rate 2 months after the second dose of the vaccine. Of the healthcare workers, 22.9% (n = 155) were seronegative. The younger the age of the participant, the higher the level of anti-SARS-CoV-2 immunoglobulin G. Furthermore, anti-SARS-CoV-2 immunoglobulin G levels were much higher in women than men.